Electrospray interface to a microfluidic substrate

Patent metadata

Field	Value
Publication number	US-9242192-B2
Application number	US-201414273040-A
Country	US
Kind code	B2
Filing date	May 8, 2014
Priority date	Mar 6, 2009
Publication date	Jan 26, 2016
Grant date	Jan 26, 2016

Abstract

An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal.

First claim

What is claimed is:

1. A microfluidic cartridge for chemical separations, comprising:
a microfluidic substrate having a chromatography channel extending therethrough and a surface with an outlet aperture for outputting an eluent of a sample passing through the channel;
an emitter assembly having an emitter including a lumen, an inlet end to receive the eluent into the lumen, and an outlet end with a spray tip to emit a spray of the eluent passing through the lumen; and
a force-applying unit applying a force to the emitter that urges the inlet end of the emitter into flush contact with the surface of the microfluidic substrate to produce a substantially leakproof path for the eluent from the outlet aperture of the microfluidic substrate into the lumen.

2. The microfluidic cartridge of claim 1 , wherein the inlet end of the emitter comprises a deformable portion having an elastic modulus that is lower than an elastic modulus of the surface of the microfluidic substrate.

3. The microfluidic cartridge of claim 1 , wherein the force-applying unit comprises a spring.

4. The microfluidic cartridge of claim 1 , wherein the lumen has a diameter that is less than a greatest dimension of the outlet aperture.

5. The microfluidic cartridge of claim 1 , wherein the outlet aperture is disposed in an edge surface of the microfluidic substrate.

6. The microfluidic cartridge of claim 1 , wherein the outlet aperture is disposed in a recessed portion of an edge surface of the microfluidic substrate.

7. The microfluidic cartridge of claim 1 , wherein the emitter assembly further comprises a fitting coupled to the emitter for receiving the force from the force-applying unit.

8. The microfluidic cartridge of claim 1 , further comprising an alignment fitting disposed adjacent to the outlet aperture of the microfluidic substrate, the alignment fitting receiving and disposing the inlet end of the emitter in alignment with the outlet aperture of the microfluidic substrate.

9. The microfluidic cartridge of claim 1 , further comprising a portable, handheld housing holding the microfluidic substrate, emitter assembly, and force-applying unit.

10. The microfluidic cartridge of claim 9 , further comprising wherein the portable, handheld housing comprises detachable first and second housing portions, the first housing portion holding the microfluidic substrate and the second housing portion holding the emitter assembly and force-applying unit.

11. The microfluidic cartridge of claim 9 , wherein the portable, handheld housing has a gas passageway with an inlet for receiving a gas through an inlet port of the housing and an outlet for delivering the gas to the spray tip.

12. The microfluidic cartridge of claim 1 , wherein the emitter assembly comprises the force-applying unit.

Assignees

• Waters Technologies Corp

Inventors

• Prentice David P
• Keene Russell L
• Koziol Stanislaw
• Michienzi Joseph D
• Linderson Paul E

Classifications

• G01N30/72

  Mass spectrometers {(mass spectrometers per se H01J49/00)} · CPC title

• B01D15/10 Primary

  characterised by constructional or operational features · CPC title

• B05B1/00

  Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means (B05B3/00, B05B5/00, B05B7/00 take precedence; devices for applying liquids or other fluent materials to surfaces by contact B05C; nozzles for ink-jet printing mechanisms B41J2/135; nozzles for liquid-dispensing, e.g. in vehicle service stations, B67D7/42) · CPC title

• B01L3/5027

  by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip · CPC title

• B01L2200/027

  for microfluidic devices · CPC title