Peptide vaccines usable for hypercholesterolemia related diseases
US-2024197844-A1 · Jun 20, 2024 · US
US9242011B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9242011-B2 |
| Application number | US-93543809-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 31, 2009 |
| Priority date | Apr 1, 2008 |
| Publication date | Jan 26, 2016 |
| Grant date | Jan 26, 2016 |
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Insulin albumin conjugates consisting of an insulin analogue, a bifunctional linker and albumin can efficiently be used to treat diabetic patients.
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What is claimed is: 1. A compound of M-Z n —Y o -Ins or formula II: Alb-M′-Z n —Y o -Ins; formula III: wherein Ins represents insulin or a human insulin analogue; wherein the human insulin analogue has a lysine residue at the C-terminal end of the A-chain (A22K), or at the C-terminal end of an extension of the A-chain; wherein the extension, compared to the A21 amino acid residue, consists of a single amino acid residue being lysine, or a lysine residue at the C-te…
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