Vmp-like sequences of pathogenic Borrelia
US-9212218-B2 · Dec 15, 2015 · US
US9241983B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9241983-B2 |
| Application number | US-201214114703-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 30, 2012 |
| Priority date | Apr 29, 2011 |
| Publication date | Jan 26, 2016 |
| Grant date | Jan 26, 2016 |
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The present invention encompasses methods and compositions for Ureaplasma infection prevention and/or treatment. In specific cases, the invention concerns vaccines for Ureaplasma , including DNA vaccines. In certain embodiments, the invention regards vaccines directed towards the multiple-banded antigen(s) of Ureaplasma.
Opening claim text (preview).
What is claimed is: 1. A method of inhibiting or reducing symptoms of Ureaplasma infection in an individual, comprising the step of delivering to the individual a therapeutically effective amount of antibodies that recognize the conserved region of Ureaplasma multiple-banded antigen or the 5′ end of the multiple-banded antigen. 2. The method of claim 1 , further comprising multiple steps of delivering antibodies to the individual. 3. The method of claim 2 , wherein the multiple deliveries are separated by one month or more. 4. The method of claim 2 , wherein the multiple deliveries are separated by days or weeks. 5. The method of claim 2 , wherein the multiple deliveries are separated by one year, two years, or ten years. 6. The method of claim 1 , wherein the delivery is into the amniotic cavity. 7. The method of claim 1 , wherein the delivery of antibodies is vaginally administered. 8. The method of claim 1 , wherein the individual is a female or male prior to a first sexual activity. 9. The method of claim 1 , wherein the individual is a female prior to pregnancy. 10. The method of claim 1 , wherein the individual is a pregnant female. 11. The method of claim 1 , wherein the antibodies recognize the 5′ end of the Ureaplasma multiple-banded antigen. 12. The method of claim 1 , wherein the antibodies recognize the Ureaplasma sequence of SEQ ID No: 4. 13. The method of claim 1 , wherein the individual is of one of the species human, cow, dog, cat, horse, pig, goat, sheep, or bird.
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