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Modified zinc finger binding proteins
US9238803B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9238803-B2 |
| Application number | US-48615806-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 13, 2006 |
| Priority date | Jan 22, 2001 |
| Publication date | Jan 19, 2016 |
| Grant date | Jan 19, 2016 |
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- Title
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Abstract
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Disclosed herein are compositions and method comprising non-canonical (e.g., non-C2H2) zinc finger proteins.
First claim
Opening claim text (preview).
What is claimed is: 1. A non-naturally-occurring zinc-finger binding protein comprising a non-canonical zinc finger, wherein: said non-canonical zinc finger component comprises the sequence X 3 -Cys-X 2-4 -Cys-X 12 -His-X 1-7 -Z-X 4 (SEQ ID NO:121), where X is any amino acid, where Z is C, where residues 6 to 12 of X 12 are engineered to bind to a target nucleic acid sequence, wherein X 1-7 is selected from the group consisting of SETG (residues 2-5 of SEQ ID NO:12), LKSLTP (residues 2-7 of SEQ ID NO:13), SEN, VRI, KRS, KRL, LRW, ITT, IKG and IGG. 2. The non-naturally-occurring zinc-finger binding protein of claim 1 , wherein the target sequence is a promoter sequence. 3. The non-naturally-occurring zinc-finger binding protein of claim 1 , wherein the zinc finger binding protein comprises three zinc fingers. 4. The non-naturally-occurring zinc-finger binding protein of claim 3 , wherein the third zinc finger comprises a non-canonical zinc finger. 5. The non-naturally-occurring zinc-finger binding protein of claim 1 , further comprising a functional domain. 6. The non-naturally-occurring zinc-finger binding protein of claim 5 , wherein the functional domain is an endonuclease. 7. A plant cell comprising the non-naturally-occurring zinc-finger binding protein of claim 1 . 8. The non-naturally occurring zinc finger binding proteins of claim 5 , wherein the functional domain is a repressive domain. 9. The non-naturally occurring zinc finger binding proteins of claim 5 , wherein the functional domain is an activation domain.
Assignees
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Classifications
containing a Zn-finger domain for DNA binding · CPC title
Methods for controlling, regulating or enhancing expression of transgenes in plant cells · CPC title
- C12N9/1007Primary
Methyltransferases (general) (2.1.1.) · CPC title
involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine · CPC title
Regulators; Modulating activity · CPC title
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Frequently asked questions
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- What does patent US9238803B2 cover?
- Disclosed herein are compositions and method comprising non-canonical (e.g., non-C2H2) zinc finger proteins.
- Who is the assignee on this patent?
- Rebar Edward, Jamieson Andrew, Sangamo Biosciences Inc
- What technology area does this patent fall under?
- Primary CPC classification C12N9/1007. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 19 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).