Trapping structures for a particle separation cell

Patent metadata

Field	Value
Publication number	US-9238185-B2
Application number	US-201414188018-A
Country	US
Kind code	B2
Filing date	Feb 24, 2014
Priority date	Sep 12, 2005
Publication date	Jan 19, 2016
Grant date	Jan 19, 2016

Abstract

Trapping structures are provided for particle separation devices that make use of traveling wave fluid flow. These trapping structures are operative to capture and collect separated particles and present them for extraction. The extraction can be accomplished in conventional manners, such as through the use of suitable sized pipettes.

First claim

The invention claimed is:

1. A device for trapping particles suspended in fluid moved through a traveling wave system, the device comprising:
at least one inlet operative to receive the fluid having particles suspended therein;
a channel extending from the inlet and operative to convey the fluid received at the inlet, the channel having at least one curve therein, the radius of curvature being such that the suspended particles collect and are collected at the at least one curve as the fluid flows through the channel; and,
at least one outlet operative to allow the fluid to flow out of the device.

2. The device as set forth in claim 1 wherein the channel is s-shaped.

3. The device as set forth in claim 1 further comprising at least one collection well positioned to receive at least a portion of the fluid and the suspended particles from the channel.

4. The device as set forth in claim 3 wherein the at least one collection well is positioned at the at least one curve.

5. The device as set forth in claim 3 wherein the collection well is configured to allow removal of collected particles.

6. The device as set forth in claim 1 wherein the outlet is operative to allow the fluid to flow to a recirculation path.

7. The device as set forth in claim 1 wherein the device is positioned within an array of devices, each device being tuned to collect particles of a predetermined size.

8. A device for trapping particles suspended in fluid moved through a traveling wave system, the device comprising:
at least one inlet operative to receive the fluid having particles suspended therein;
at least one channel extending from the inlet and operative to convey the fluid received at the inlet, the channel being curved to allow for collection of suspended particles in a curved portion as the fluid flows through the channel; and,
at least one outlet operative to allow the fluid to flow out of the device.

9. The device as set forth in claim 8 further comprising a well operative to collect particles suspended in the fluid.

10. The device as set forth in claim 9 wherein the well is located along the at least one channel.

11. The device as set forth in claim 9 wherein the well is positioned at an end of the at least one channel opposite the inlet.

12. The device as set forth in claim 9 wherein the well is configured to allow removal of collected particles.

13. The device as set forth in claim 8 wherein the device is positioned within an array of devices, each device being tuned to collect particles of a predetermined size.

14. A device for trapping particles suspended in fluid moved through a traveling wave system, the device comprising:
at least one inlet operative to receive the fluid having particles suspended therein;
a first channel extending from the inlet and operative to convey the fluid received at the inlet;
a collection well positioned to receive at least a portion of the fluid and the suspended particles from the first channel;
a second channel parallel to the first channel, the second channel positioned to receive at least a remaining portion of the fluid;
a dividing wall between the first channel and the second channel, the dividing wall being configured to allow at least the remaining portion of the fluid to flow over the dividing wall from the first channel to the second channel and,
a recirculation path for the second fluid connected to the second channel.

15. A device for trapping particles suspended in fluid moved through a traveling wave system, the device comprising:
at least one inlet operative to receive the fluid having particles suspended therein;
a channel extending from the inlet and operative to convey the fluid received at the inlet, the channel having at least one curve therein, the radius of curvature being such that the suspended particles collect and are collected at the at least one curve as the fluid flows through the channel; and,
at least one outlet operative to allow the fluid to flow out of the device to a recirculation path.

16. A device for trapping particles suspended in fluid moved through a traveling wave system, the device comprising:
at least one inlet operative to receive the fluid having particles suspended therein;
at least one channel extending from the inlet and operative to convey the fluid received at the inlet, the channel being curved to allow for collection of suspended particles in a curved portion as the fluid flows through the channel; and,
at least one outlet operative to allow the fluid to flow out of the device to a recirculation path.

17. A device for trapping particles suspended in fluid moved through a traveling wave system, the device comprising:
at least one inlet operative to receive the fluid having particles suspended therein;
a channel extending from the inlet and operative to convey the fluid received at the inlet, the channel having at least one curve with a well positioned therein, the radius of curvature being such that the suspended particles collect and are collected in the well at the at least one curve as the fluid flows through the channel; and,
at least one outlet operative to allow the fluid to flow out of the device.

18. A device for trapping particles suspended in fluid moved through a traveling wave system, the device comprising:
at least one inlet operative to receive the fluid having particles suspended therein;
at least one channel extending from the inlet and operative to convey the fluid received at the inlet, the channel being curved with a well to allow for collection of suspended particles in the well as the fluid flows through the channel; and,
at least one outlet operative to allow the fluid to flow out of the device.

Assignees

• Palo Alto Res Ct Inc

Inventors

• Lean Meng H
• Seo Jeonggi

Classifications

• B03C5/028

  using travelling electric fields, i.e. travelling wave dielectrophoresis [TWD] · CPC title

• B01L2200/0668

  Trapping microscopic beads · CPC title

• B01D21/0042 Primary

  Baffles or guide plates · CPC title

• B03B5/00

  Washing granular, powdered or lumpy materials; Wet separating (separating by pneumatic tables or by pneumatic jigs B03B4/00) · CPC title

• B03C5/005

  Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength · CPC title