Compositions and methods for viral sensitization
US-2024360115-A1 · Oct 31, 2024 · US
Retargeting of rat parvovirus H-1PV to cancer cells through genetic engineering of its capsid
US9234183B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9234183-B2 |
| Application number | US-201313859678-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 9, 2013 |
| Priority date | Oct 21, 2010 |
| Publication date | Jan 12, 2016 |
| Grant date | Jan 12, 2016 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
Described is a parvovirus, in particular a H-IPV, that can be genetically retargeted through modification of its capsid, which is useful in cancer therapy.
First claim
Opening claim text (preview).
The invention claimed is: 1. An H-1 rat parvovirus (H-1PV) comprising a mutation in the polypeptide sequence of the VP proteins, wherein the mutation is at one of or both positions corresponding to I367 and H373 of H-1PV VP2 protein. 2. The H-1 rat parvovirus according to claim 1 , wherein the mutation is an I367S mutation. 3. The H-1 rat parvovirus according to claim 1 , wherein the mutation is an H373R mutation. 4. The H-1 rat parvovirus according to claim 1 , wherein the parvovirus further comprises a foreign peptide or protein with high-affinity for a receptor expressed in a tumor cell. 5. The H-1 rat parvovirus according to claim 4 , wherein the foreign peptide or protein comprises the amino acid sequence RGD. 6. The H-1 rat parvovirus according to claim 4 , wherein the foreign peptide or protein is inserted at position A 441 of the VP2 protein (corresponding to A583 of the VP1 protein) of the parvovirus. 7. A pharmaceutical composition containing the H-1 rat parvovirus according to claim 1 . 8. A method for treating cancer in a human, comprising the step of administering to a human the H-1 rat parvovirus according to claim 1 . 9. The method according to claim 8 , wherein the cancer is a melanoma, a brain tumor, mammary carcinoma or cervical carcinoma. 10. The method according to claim 8 , wherein the cancer is a glioblastoma.
Assignees
Inventors
Classifications
New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes · CPC title
- C12N7/00Primary
Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof (preparing medicinal viral antigen or antibody compositions, e.g. virus vaccines, A61K39/00) · CPC title
Viruses as such, e.g. new isolates, mutants or their genomic sequences · CPC title
Antineoplastic agents · CPC title
from viruses · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9234183B2 cover?
- Described is a parvovirus, in particular a H-IPV, that can be genetically retargeted through modification of its capsid, which is useful in cancer therapy.
- Who is the assignee on this patent?
- Deutsches Krebsforsch, Deutsches Krebsforsch
- What technology area does this patent fall under?
- Primary CPC classification C12N7/00. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 12 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).