Hybrid microfluidic assemblies

Patent metadata

Field	Value
Publication number	US-9233372-B2
Application number	US-201214126116-A
Country	US
Kind code	B2
Filing date	Jun 12, 2012
Priority date	Jun 14, 2011
Publication date	Jan 12, 2016
Grant date	Jan 12, 2016

Abstract

Embodiments of hybrid microfluidic assemblies comprise at least one microstructure that is formed of transparent material and is substantially free of non-transparent material and further comprise at least one microstructure that is formed of non-transparent material and is substantially free of transparent material.

First claim

The invention claimed is:

1. A hybrid microfluidic assembly comprising a microfluidic assembly housing and a plurality of microstructures disposed in the microfluidic assembly housing, each microstructure comprising one or more internal fluid passages, wherein:
selected ones of the plurality of microstructures are in fluid communication with at least one other microstructure;
at least one of the selected microstructures comprises transparent material and is substantially free of non-transparent material; and
at least one of the selected microstructures comprises non-transparent material and is substantially free of transparent material.

2. The hybrid microfluidic assembly of claim 1 , wherein the transparent material comprises glass and the non-transparent material comprises ceramic.

3. The hybrid microfluidic assembly of claim 2 , wherein the ceramic comprises silicon carbide.

4. The hybrid microfluidic assembly of claim 1 , wherein at least one microstructure is fluidically connected to at least another microstructure by an interconnecting fluid conduit.

5. The hybrid microfluidic assembly of claim 4 , wherein the interconnecting fluid conduit comprises a removable interconnecting fluid conduit, the removable interconnecting fluid conduit comprising tubing.

6. The hybrid microfluidic assembly of claim 4 , wherein the interconnecting fluid conduit consists of a material that is substantially metal free.

7. The hybrid microfluidic assembly of any of claim 1 , wherein at least two adjacent microstructures are mechanically stacked.

8. The hybrid microfluidic assembly of claim 7 , wherein the at least two mechanically stacked microstructures are fluidically connected by an O-ring seal compressed between said adjacent microstructures.

9. The hybrid microfluidic assembly of claim 1 , wherein at least two adjacent microstructures are permanently stacked.

10. The hybrid microfluidic assembly of claim 9 , wherein the permanently stacked microstructures are sealed together by a connecting pad that is positioned between said adjacent microstructures, wherein said adjacent microstructures are fluidically connected to one another by a fluid passage within the connecting pad.

11. The hybrid microfluidic assembly of claim 10 , wherein the connecting pad comprises a glass pad fused to the adjacent microstructures.

12. The hybrid microfluidic assembly of claim 1 , wherein each of the microstructures further comprises a second internal fluid passage that is fluidically connected to a thermal fluid source.

13. The hybrid microfluidic assembly of claim 1 , wherein the hydraulic diameters of the internal fluid passages range from approximately 0.4 mm to 12 mm.

14. The hybrid microfluidic assembly of claim 1 , wherein at least one of the at least two microstructures is moveably disposed in the microfluidic assembly housing such that the at least two microstructures are moveable with respect to each other.

15. The hybrid microfluidic assembly of claim 1 , wherein the microstructures may be interchangeably positioned to form different microfluidic assembly configurations.

16. A hybrid microfluidic assembly comprising a microfluidic assembly housing and a plurality of microstructures disposed in the microfluidic assembly housing, each microstructure comprising one or more internal fluid passages, wherein:
selected ones of the plurality of microstructures are in fluid communication with at least one other microstructure;
at least one of the microstructures comprises transparent material and is substantially free of non-transparent material;
the remaining microstructures comprise non-transparent material and are substantially free of transparent material, wherein at least one microstructure comprises non-transparent material and is substantially free of transparent material; and
wherein the microstructures may be interchangeably positioned to form different microfluidic assembly configurations.

17. The hybrid microfluidic assembly of claim 16 , wherein the transparent material comprises glass and the non-transparent material comprises ceramic.

18. The hybrid microfluidic assembly of claim 17 , wherein the ceramic comprises silicon carbide.

19. A method of processing fluids or mixtures of fluids with a hybrid microfluidic assembly, wherein the method comprises:
introducing a fluid into a hybrid microfluidic assembly, wherein the hybrid microfluidic assembly comprises a microfluidic assembly housing and a plurality of microstructures disposed in the microfluidic assembly housing, each microstructure comprising one or more internal fluid passages, wherein selected ones of the plurality of microstructures are in fluid communication with at least one other microstructure, at least one of the microstructures comprises transparent material and is substantially free of non-transparent material, and at least one of the microstructures comprises non-transparent material and is substantially free of transparent material;
processing the fluid within the hybrid microfluidic assembly, wherein processing comprises mixing, separating, extracting, crystallizing, precipitating, or combinations thereof.

20. The method of processing fluids or mixtures of fluids with a hybrid microfluidic assembly of claim 19 , wherein the method further comprises monitoring the process through at least one of the microstructures comprising transparent material.

Assignees

• Guidat Roland
• Lobet Olivier
• Marques Paulo Gaspar Jorge
• Woehl Pierre
• Corning Inc

Inventors

• Guidat Roland
• Lobet Olivier
• Marques Paulo Gaspar Jorge
• Woehl Pierre

Classifications

• B01L3/5027 Primary

  by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip · CPC title

• B01L2200/025

  Align devices or objects to ensure defined positions relative to each other · CPC title

• B81C99/0095

  Aspects relating to the manufacture of substrate-free structures, not covered by groups B81C99/008 - B81C99/009 · CPC title

• Y10T137/0318

  Processes · CPC title

• B01L2200/028

  Modular arrangements · CPC title