Method of treating and diagnosing Parkinson's disease and related dysautonomic disorders

Patent metadata

Field	Value
Publication number	US-9233146-B2
Application number	US-201414493734-A
Country	US
Kind code	B2
Filing date	Sep 23, 2014
Priority date	Aug 14, 2000
Publication date	Jan 12, 2016
Grant date	Jan 12, 2016

Abstract

A method for treating a Parkinson's patient with digestive/pancreatic enzymes involves administering an effective amount of digestive/pancreatic enzymes to an individual having the disorder in order to improve a symptom of the disorder. In addition, a method is provided for determining whether an individual has, or may develop, Parkinson's disease or related dysautonomic disorders and for determining whether an individual will benefit from the administration of pancreatic/digestive enzymes to treat the dysautonomic disorder.

First claim

The invention claimed is:

1. A method of assaying and treating an individual having a Dysautonomic Disorder comprising the steps of:
measuring a level of fecal chymotrypsin in a stool sample of the individual;
comparing the level of fecal chymotrypsin with a normal fecal chymotrypsin level; and
administering a pharmaceutical composition comprising a therapeutically effective amount of digestive enzymes to the individual if the level of fecal chymotrypsin in the individual is less than the normal fecal chymotrypsin level, wherein the digestive enzymes comprise a protease, an amylase and a lipase.

2. The method of claim 1 , wherein the level of fecal chymotrypsin in the stool sample is measured using a technique selected from the group consisting of enzymatic photospectrometry, colorimetry, treatment with substrates, assays, and a combination thereof.

3. The method of claim 1 , wherein the normal fecal chymotrypsin level is approximately 8.4 U/gram.

4. The method of claim 1 , wherein the protease comprises chymotrypsin and trypsin.

5. The method of claim 1 , wherein the amount of amylase in the pharmaceutical composition comprises from about 10,000 to about 70,000 USP units/dose.

6. The method of claim 1 , wherein the amount of protease in the pharmaceutical composition comprises from about 10,000 to about 80,000 USP units/dose.

7. The method of claim 1 , wherein the amount of lipase in the pharmaceutical composition comprises from about 4,000 to about 80,000 USP units/dose.

8. The method of claim 1 , wherein the digestive enzymes comprise pancreatin.

9. The method of claim 8 , wherein the amount of pancreatin in the pharmaceutical composition comprises from about 2,000 to about 6,000 USP units/dose.

10. The method of claim 4 , wherein the amount of chymotrypsin in the pharmaceutical composition comprises from about 2 to about 7 mg/dose.

11. The method of claim 4 , wherein the amount of trypsin in the pharmaceutical composition comprises from about 60 to about 100 mg/dose.

12. The method of claim 1 , wherein the method treats a symptom of the Dysautonomic Disorder selected from the group consisting of constipation, tremors, falls, difficulty in ambulation and a combination thereof.

13. The method of claim 1 , wherein the Dysautonomic Disorder is Parkinson's Disease.

Assignees

• Curemark Llc

Inventors

• Fallon Joan M

Classifications

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• G01N33/52

  Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper {and including single- and multilayer analytical elements (immunological elements G01N33/54386; involving labelled immunochemicals G01N33/58; for haemoglobin or occult blood G01N33/72)} · CPC title

• C12Y304/21001

  Chymotrypsin (3.4.21.1) · CPC title

• C12Y304/21004

  Trypsin (3.4.21.4) · CPC title

• A23V2200/322

  having an effect on the health of the nervous system or on mental function · CPC title