Biomaterials containing calcium phosphate

Patent metadata

Field	Value
Publication number	US-9233124-B2
Application number	US-200913000653-A
Country	US
Kind code	B2
Filing date	Jun 22, 2009
Priority date	Jun 23, 2008
Publication date	Jan 12, 2016
Grant date	Jan 12, 2016

Abstract

The invention relates to a biomaterial containing calcium phosphate, in particular hydroxyapatite or a material containing hydroxyapatite, such as biphasic calcium phosphates and calcium phosphate cements, and to the use thereof for the production of an implant or for fitting a prosthesis for the purpose of bone tissue regeneration.

First claim

The invention claimed is:

1. A material for bone tissue regeneration, the material consisting of
a mixture of an aqueous solution having a calcium comprising coagulating agent and a support material selected from the group consisting of hydroxyapatite (HA) and a biphasic calcium phosphate (BCP), and a combination thereof, wherein the material is a paste and
wherein the amount of coagulating agent in the mixture is from 2.5 to 60 μmol of calcium per gram of HA, BCP, or a combination thereof.

2. The material of claim 1 , wherein the coagulating agent is CaCl 2 .

3. The material of claim 1 , wherein the support is in granule form.

4. A method for filling a bone defect, the method comprising implanting the material of claim 1 into bone tissue.

5. A combination, consisting of the material of claim 1 and an osteosynthesis.

6. A method of producing bone tissue, comprising combining, in vitro or ex vivo, the material of claim 1 with bone cells.

7. A method of producing bone implant, comprising combining, in vitro or ex vivo, the material of claim 1 with bone cells or a prosthesis mould.

8. The material of claim 1 , wherein the coagulating agent is present in a proportion ranging from 5 to 40 μmol of calcium per gram of HA or BCP.

Assignees

• Balaguer Thierry
• Rochet Nathalie
• Carle Georges
• Centre Nat Rech Scient
• Ct Hospitalier Universitaire Nice

Inventors

• Balaguer Thierry
• Rochet Nathalie
• Carle Georges

Classifications

• A61L2300/102

  Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates · CPC title

• A61L27/12 Primary

  Phosphorus-containing materials, e.g. apatite · CPC title

• A61B17/8805

  for introducing fluid filler into bone or extracting it (A61B17/7097, A61B17/8833 take precedence) · CPC title

• A61K33/42 Primary

  Phosphorus; Compounds thereof · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title