Polymer scaffold degradation control via chemical control

Patent metadata

Field	Value
Publication number	US-9228042-B2
Application number	US-201414147983-A
Country	US
Kind code	B2
Filing date	Jan 6, 2014
Priority date	Nov 10, 2009
Publication date	Jan 5, 2016
Grant date	Jan 5, 2016

Abstract

A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses. Copolymers having a synthesis route which enables one to fine tune the degradation rate by selecting the specific stoichiometry of the monomers in the resulting copolymer are also described. The disclosure also provides a novel synthesis route for maleoyl chloride which yields monomers suitable for use in the copolymer synthesis methods described herein.

First claim

What is claimed is:

1. A biodegradable, biocompatible construct comprising a copolymer comprising a controlled, non-arbitrary ratio of repeating units of both maleate and fumarate.

2. The construct of claim 1 wherein the copolymer has a rate of degradation that is faster than poly(propylene fumarate) (PPF).

3. A biodegradable, biocompatible construct comprising a copolymer comprising repeating units of both maleate and fumarate wherein the construct has been formed by electrospinning the copolymer and photocrosslinking the polymer while the polymer fibers are formed.

4. The construct of claim 1 wherein the copolymer is formed by blending malonyl and fumaryl chloride monomers with a polyalcohol species at low temperature with an inert gas sparge.

5. The construct of claim 4 wherein the desired density of the formed copolymer is determined by the controlled, non-arbitrary ratio.

6. The construct of claim 4 wherein the polyalcohol species is butane diol or glycerol.

7. The construct of claim 3 wherein the copolymer has a rate of degradation that is faster than poly(propylene fumarate) (PPF).

8. The construct of claim 3 wherein the copolymer is formed by blending malonyl and fumaryl chloride monomers with a polyalcohol species at low temperature with an inert gas sparge.

9. The construct of claim 8 wherein the malonyl and fumaryl chloride monomers are blended together in a known ratio.

10. The construct of claim 9 wherein the desired density of the formed copolymer is determined by the known ratio.

11. The construct of claim 8 wherein the polyalcohol species is butane diol or glycerol.

Assignees

• Hedberg-Dirk Elizabeth L
• Dirk Shawn
• Cicotte Kirsten
• Stc Unm

Inventors

• Hedberg-Dirk Elizabeth L
• Dirk Shawn
• Cicotte Kirsten

Classifications

• C08G63/52 Primary

  Polycarboxylic acids or polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation · CPC title

• C08F222/10 Primary

  Esters · CPC title