Tricyclic heterocycles as bet protein inhibitors
US-2015175604-A1 · Jun 25, 2015 · US
Tricyclic heterocycles as bet protein inhibitors
US9227985B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9227985-B2 |
| Application number | US-201414212721-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 14, 2014 |
| Priority date | Mar 15, 2013 |
| Publication date | Jan 5, 2016 |
| Grant date | Jan 5, 2016 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present invention relates to tricyclic heterocycles of Formula (I): which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound having the structure: or a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient. 3. A compound which is (4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one, or a pharmaceutically acceptable salt thereof. 4. A pharmaceutical composition comprising the compound of claim 3 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient. 5. A compound which is (4R)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one, or a pharmaceutically acceptable salt thereof. 6. A pharmaceutical composition comprising the compound of claim 5 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient. 7. The compound of claim 1 which is: 8. A pharmaceutical composition comprising the compound of claim 7 and at least one pharmaceutically acceptable carrier or excipient. 9. A compound which is (4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one. 10. A pharmaceutical composition comprising the compound of claim 9 and at least one pharmaceutically acceptable carrier or excipient. 11. A compound having the structure: or a pharmaceutically acceptable salt thereof. 12. A pharmaceutically composition comprising the compound of claim 11 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient. 13. A compound having the structure: 14. A pharmaceutical composition comprising the compound of claim 13 and at least one pharmaceutically acceptable carrier or excipient.
Assignees
Inventors
Classifications
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title
Peri-condensed systems · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
ortho- or peri-condensed with heterocyclic ring systems · CPC title
Antineoplastic agents · CPC title
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Frequently asked questions
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- What does patent US9227985B2 cover?
- The present invention relates to tricyclic heterocycles of Formula (I): which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.
- Who is the assignee on this patent?
- Incyte Corp, Incyte Holdings Corp
- What technology area does this patent fall under?
- Primary CPC classification C07D498/06. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 05 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 5 related publications on this page (citations in our corpus or others sharing the same primary CPC).