Methods for Nucleic Acid Cleavage
US-2024417778-A1 · Dec 19, 2024 · US
Biological specimen collection and transport system and method of use
US9212399B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9212399-B2 |
| Application number | US-201414149278-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 7, 2014 |
| Priority date | Oct 1, 2007 |
| Publication date | Dec 15, 2015 |
| Grant date | Dec 15, 2015 |
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Abstract
Official abstract text for this publication.
Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using these compositions as one-step formations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or assay. The disclosed compositions safely facilitate rapid sample collection, and provide extended storage and transport of the samples at ambient or elevated temperature without contamination of the sample or degradation of the nucleic acids contained therein. This process particularly facilitates the collection of specimens from remote locations, and under conditions previously considered hostile for presenting the integrity of nucleic acids released from lysed biological samples without the need of refrigeration or freezing prior to molecular analysis.
First claim
Opening claim text (preview).
What is claimed is: 1. A stock solution of an aqueous composition comprising: a chaotrope, a detergent, a reducing agent, a chelator, and a buffer, wherein the stock composition, when diluted with a sample containing nucleic acids, nucleases and proteins, denatures the proteins of the sample, inactivates the nucleases of the sample, kills pathogens that may be present in the sample, and does not degrade the nucleic acids of the sample. 2. The stock solution of…
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Classifications
- C12Q1/6806Primary
Chemistry & Metallurgy · mapped topic
- C12Q1/70Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US9212399B2 cover?
- Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using these compositions as one-step formations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or as…
- Who is the assignee on this patent?
- Longhorn Vaccines & Diagnostics Llc
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/6806. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 15 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).