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Human micrornas and methods for inhibiting same
US9212360B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9212360-B2 |
| Application number | US-201313959064-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 5, 2013 |
| Priority date | Apr 29, 2005 |
| Publication date | Dec 15, 2015 |
| Grant date | Dec 15, 2015 |
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Abstract
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The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a microRNA shown in SEQ ID NOs: 1-94; 281-374; 467-481; 497-522; or 549, except that up to thirty percent of the bases may be wobble bases, and up to 10% of the contiguous bases may be non-complementary. The invention further relates to modified single stranded microRNA molecules, isolated single stranded anti-microRNA molecules and isolated microRNP molecules. In another embodiment, the invention relates to a method for inhibiting microRNP activity in a cell.
First claim
Opening claim text (preview).
What is claimed is: 1. An isolated nucleic acid molecule comprising a microRNA having SEQ ID NO: 294, said molecule having no more than 50 nucleotides, wherein the molecule is modified for increased nuclease resistance. 2. An isolated nucleic acid molecule comprising a hairpin precursor microRNA having SEQ ID NO: 388, said molecule having no more than 300 nucleotides, wherein the molecule is modified for increased nuclease resistance. 3. An i…
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Chemistry & Metallurgy · mapped topic
- C12N15/113Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9212360B2 cover?
- The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a microRNA shown in SEQ ID NOs: 1-94; 281-374; 467-481; 497-522; or 549, except that up to thirty percent of the bases may be wobble bases, and up to 10% of the contiguous bases may be non-complementary. The invention further relates to modified single stranded microRNA molecules…
- Who is the assignee on this patent?
- Univ Rockefeller, Univ Rockefeller
- What technology area does this patent fall under?
- Primary CPC classification C12N15/113. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 15 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).