Process for the preparation of dabigatran etexilate mesylate and polymorphs of intermediates thereof

US9212166B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9212166-B2
Application numberUS-201314373163-A
CountryUS
Kind codeB2
Filing dateJan 21, 2013
Priority dateJan 20, 2012
Publication dateDec 15, 2015
Grant dateDec 15, 2015

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  2. Abstract

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Abstract

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The present invention provides crystalline form of intermediates of Formula 2A, The present invention also provides process for the preparation of dabigatran etexilate mesylate; polymorph of intermediates thereof; particularly processes for the preparation of crystalline form of intermediates. The present invention also relates to the use of crystalline intermediates for the preparation of dabigatran etexilate mesylate.

First claim

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We claim: 1. A process for preparation of dabigatran etexilate of Formula (F) or a pharmaceutically acceptable salt thereof, the process comprising the steps of: (a) treating crystalline ethyl 3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate of Formula (2B) with an acid in organic solvent to obtain a…

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What does patent US9212166B2 cover?
The present invention provides crystalline form of intermediates of Formula 2A, The present invention also provides process for the preparation of dabigatran etexilate mesylate; polymorph of intermediates thereof; particularly processes for the preparation of crystalline form of intermediates. The presen…
Who is the assignee on this patent?
Cadila Healthcare Ltd
What technology area does this patent fall under?
Primary CPC classification C07D401/12. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Dec 15 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).