Materials and methods for diagnosis
US-2024103020-A1 · Mar 28, 2024 · US
US9207246B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9207246-B2 |
| Application number | US-201313865425-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 18, 2013 |
| Priority date | Dec 31, 2008 |
| Publication date | Dec 8, 2015 |
| Grant date | Dec 8, 2015 |
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A composition of matter for use in an immunoassay devices and method comprising a signal antibody, e.g., FAB fragment, covalently linked to a first nucleotide; and one or more signal elements, e.g., signal enzymes such as ALP or fluorescent dyes, each covalently linked to a second nucleotide, wherein the first nucleotide has one or more repeated sequences, and the second nucleotide is bound to one of the one or more repeated sequences on said first nucleotide, and wherein the ratio of the signal antibody to the signal element is controlled by the number of repeated sequences.
Opening claim text (preview).
What is claimed is: 1. A single-use cartridge for performing an immunoassay, comprising: a sample entry port for receiving a blood sample suspected of containing a target analyte, a conduit containing an electrode, a region containing a wash fluid, a waste chamber, immobilized first antibody capable of binding to said target analyte, second antibody disposed in a solubilizing agent disposed within said conduit and capable of binding to said target analyte, wherein the s…
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