Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl-trna synthetases
US-2015361411-A1 · Dec 17, 2015 · US
US9205136B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9205136-B2 |
| Application number | US-201414152544-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 10, 2014 |
| Priority date | Mar 31, 2000 |
| Publication date | Dec 8, 2015 |
| Grant date | Dec 8, 2015 |
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Methods of enhancing angiogenesis utilizing carboxy-terminal truncated human tyrosyl-tRNA synthetase (TyrRS) are disclosed. The truncated human TyrRS polypeptides comprise residues 1-364 or residues 1-343 of full length human TyrRS (SEQ ID NO: 2).
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We claim: 1. A method for enhancing angiogenesis in a mammal to achieve a therapeutic effect; the method comprising the step of administering to the mammal an effective amount of a polypeptide which consists essentially of residues 1 to 364 of SEQ ID NO:2 or a dimer thereof encoded by a nucleic acid comprising a coding region consisting of a nucleotide sequence at least 95% identical to a sequence selected from the group consisting of: (a) a polynucleotide encoding a polypeptide…
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