Process for cabazitaxel
US-9815806-B2 · Nov 14, 2017 · US
US9199954B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9199954-B2 |
| Application number | US-201113995445-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 22, 2011 |
| Priority date | Dec 22, 2010 |
| Publication date | Dec 1, 2015 |
| Grant date | Dec 1, 2015 |
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The invention relates to (among other things) non-ring hydroxy substituted taxanes and methods for synthesizing the same. The invention further relates to conjugating the non-ring hydroxyl substituted taxanes to a water-soluble, non-peptidic polymer.
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What is claimed is: 1. A method comprising esterifying a baccatin III compound of Formula III, which compound is encompassed by the formula: wherein: R 1 is selected from the group consisting of H, a hydroxy protecting group, a C 1-6 organic radical; R 2 is selected from the group consisting of H, a hydroxy protecting group, a C 1-6 organic radical; and R 3 is…
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