Cellular Adjuvants for Viral Infection
US-2024299521-A1 · Sep 12, 2024 · US
US9199897B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9199897-B2 |
| Application number | US-201113696591-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 12, 2011 |
| Priority date | May 12, 2010 |
| Publication date | Dec 1, 2015 |
| Grant date | Dec 1, 2015 |
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Official abstract text for this publication.
An improved method for preparing squalene from a squalene-containing composition, said method comprising the steps of (a) a purification distillation carried out at a temperature T 1 ; (b) a denaturing distillation carried out at a temperature T 2 ; wherein steps (a) and (b) may be performed in either order; T 1 and T 2 are sufficient to cause squalene to boil; T 2 >T 1 ; and T 2 >200° C.
Opening claim text (preview).
The invention claimed is: 1. A method for manufacturing squalene suitable for pharmaceutical use in a vaccine which comprises subjecting fish oil comprising squalene to: (i) a purification distillation carried out at near vacuum; and (ii) a denaturing distillation carried out at a temperature greater than or equal to 210° C. at a pressure of 0.8 to 5.0 mmHg, wherein the temperature in the denaturing distillation exceeds the temperature in the purification distillation; and whe…
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