Morphine formulations
US-9072781-B2 · Jul 7, 2015 · US
US9192608B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9192608-B2 |
| Application number | US-201514715277-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 18, 2015 |
| Priority date | Mar 14, 2013 |
| Publication date | Nov 24, 2015 |
| Grant date | Nov 24, 2015 |
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Provided herein, generally, are pharmaceutical formulations, e.g., injectable pharmaceutical formulations with improved stability, comprising morphine sulfate or a hydrate thereof, and methods of producing and using the same. Also provided herein are kits comprising the formulations, e.g., injectable morphine formulations.
Opening claim text (preview).
What is claimed is: 1. A method of reducing pain in a subject, comprising: administering to the subject an injectable pharmaceutical formulation comprising per mL (a) from about 2 mg to about 10 mg of morphine sulfate or a hydrate thereof; (b) sodium chloride; (c) a buffering agent in an amount which provides a molar ratio of morphine sulfate to the buffering agent from about 0.4 to about 1.3 and is in an amount sufficient to provide a pH of 5 to the formulation; (d) disodiu…
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