Heterocyclic modulators of lipid synthesis
US-2024400552-A1 · Dec 5, 2024 · US
US9187472B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9187472-B2 |
| Application number | US-201313891366-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 10, 2013 |
| Priority date | May 11, 2012 |
| Publication date | Nov 17, 2015 |
| Grant date | Nov 17, 2015 |
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Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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What is claimed is: 1. A compound, or a therapeutically acceptable salt thereof, selected from the group consisting of: 5-[1-({3,5-dimethyl-7-[2-(methylamino)ethoxy]tricyclo[3.3.1.1 3,7 ]dec-1-yl}methyl)-5-methyl-1H-pyrazol-4-yl]-N-(imidazo[1,2-a]pyridin-7-ylmethyl)thiophene-2-carboxamide; N-(imidazo[1,2-a]pyridin-7-ylmethyl)-5-[1-({4-methyl-1-[2-(piperazin-1-yl)ethyl]piperidin-4-yl}methyl)-1H-pyrazol-4-yl]thiophene-2-carboxamide; S-(2-{4-[(4-{5-[(imidazo[1,2-a]pyridin-7-ylme…
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