Devices and methods for multiplexing chemical synthesis
US-2024091731-A1 · Mar 21, 2024 · US
In vitro evolution in microfluidic systems
US9186643B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9186643-B2 |
| Application number | US-201213692615-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 3, 2012 |
| Priority date | Oct 8, 2004 |
| Publication date | Nov 17, 2015 |
| Grant date | Nov 17, 2015 |
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Abstract
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The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalizing genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for producing an encapsulated gene product, comprising the steps of: (a) providing within a first microcapsule within a microfluidic channel a first genetic element encoding a first gene product, the microcapsule comprising an aqueous fluid substantially surrounded by an immiscible fluorinated oil including a fluorinated polymer surfactant, wherein the microcapsule is able to contact without fusing with another microcapsule due to presence of…
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Operations & Transport · mapped topic
Operations & Transport · mapped topic
- B01J19/0046Primary
Operations & Transport · mapped topic
Operations & Transport · mapped topic
Operations & Transport · mapped topic
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Frequently asked questions
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- What does patent US9186643B2 cover?
- The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalizing genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vi…
- Who is the assignee on this patent?
- Medical Res Council, Harvard College
- What technology area does this patent fall under?
- Primary CPC classification B01J19/0046. Mapped technology areas include Operations & Transport.
- When was this patent published?
- Publication date Tue Nov 17 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).