Pasty bone replacement material

Patent metadata

Field	Value
Publication number	US-9186437-B2
Application number	US-201313940904-A
Country	US
Kind code	B2
Filing date	Jul 12, 2013
Priority date	Jul 20, 2012
Publication date	Nov 17, 2015
Grant date	Nov 17, 2015

Abstract

The present invention relates to a pasty composition, at least containing particles of at least one calcium salt, whereby the particles of the at least one calcium salt
are at least partly coated with at least one saturated fatty acid ester (a) that has a melting temperature of at least 45° C., and said particles that are at least partly coated with the saturated fatty acid ester (a) are mixed with at least one saturated fatty acid ester (b) that has a melting temperature below 25° C.

to form a pasty composition.

The invention also relates to a method for producing a pasty composition, the pasty composition obtainable through said method, and the use of a pasty composition as bone replacement material.

First claim

The invention claimed is:

1. A pasty composition, at least containing comprising particles of at least one calcium salt, whereby the particles of the at least one calcium salt are at least partly coated with at least one saturated fatty acid ester (a) that has a melting temperature of at least 45° C., wherein the saturated fatty acid ester (a) is selected from the group consisting of glycerol-1,2,3-trimyristate, glycerol-1,2,3-tripalmitate, glycerol-1,2,3-tristearate, glycerol-1,2,3-tribehenate, myristic acid myristylester, palmitic acid palmitoylester, and a mixture of at least two of these substances, and said particles that are at least partly coated with the saturated fatty acid ester (a) are mixed with at least one saturated fatty acid ester (b) that has a melting temperature below 25° C., wherein the saturated fatty acid ester (b) is selected from the group consisting of glycerol-1,2,3-trioctoate, glycerol-1,2,3-tridecanoate, myristic acid isopropylester, myristic acid methylester, myristic acid ethylester, palmitic acid isopropylester, palmitic acid methylester, palmitic acid ethylester, stearic acid isopropylester, or mixtures of at least two of the preceding components
to form a pasty composition.

2. The pasty composition according to claim 1 , whereby the particles of the calcium salt are not hydraulically-setting.

3. The pasty composition according to claim 1 wherein the particles of the calcium salt are selected from the group consisting of β-tricalcium-phosphate, α-tricalcium-phosphate, hydroxyapatite, octacalcium-phosphate, calcium carbonate, dolomite, calcium sulfate dihydrate, and mixtures of at least two of these substances.

4. The pasty composition according to claim 1 wherein the particle size of at least 50% by weight of the particles of the calcium salt as determined by sieve analysis is less than 1 mm.

5. The pasty composition according to claim 4 wherein the particle size of at least 50% by weight of the particles of the calcium salt as determined by sieve analysis is less than 100 μm.

6. The pasty composition according to claim 5 wherein the particle size of at least 50% by weight of the particles of the calcium salt as determined by sieve analysis is less than 64 μm.

7. The pasty composition according to claim 1 wherein the composition further comprises additives aside from the particles of a calcium salt and the saturated fatty acid esters (a) and (b).

8. The pasty composition according to claim 1 wherein the composition comprises
(α1) 50 to 80% by weight of the particles of a calcium salt;
(α2) 0.1 to 25% by weight of the saturated fatty acid ester (a);
(α3) 15 to 40% by weight of the saturated fatty acid ester (b); and
(α4) 0 to 10% by weight of an additive;
whereby the amounts of components (α1) add up to (α4) 100% by weight.

9. A method for producing a pasty composition, comprising at least the procedural steps of:
(i) providing particles of at least one calcium salt;
(ii) coating, at least partly, the particles of the at least one calcium salt with a saturated fatty acid ester (a) that has a melting temperature of at least 45° C., wherein the saturated fatty acid ester (a) is selected from the group consisting of glycerol-1,2,3-trimyristate, glycerol-1,2,3-tripalmitate, glycerol-1,2,3-tristearate, glycerol-1,2,3-tribehenate, myristic acid myristylester, palmitic acid palmitoylester, and a mixture of at least two of these substances; and
(iii) mixing the particles of the at least one calcium salt that are at least partly coated with the saturated fatty acid ester (a) with at least one saturated fatty acid ester (b) that has a melting temperature below 25° C., wherein the saturated fatty acid ester (b) is selected from the group consisting of glycerol-1,2,3-trioctoate, glycerol-1,2,3-tridecanoate, myristic acid isopropylester, myristic acid methylester, myristic acid ethylester, palmitic acid isopropylester, palmitic acid methylester, palmitic acid ethylester, stearic acid isopropylester, or mixtures of at least two of the preceding components, while forming a pasty composition.

10. The method according to claim 9 , wherein the particles of the calcium salt are selected from the group consisting of β-tricalcium-phosphate, α-tricalcium-phosphate, hydroxyapatite, octacalcium-phosphate, calcium carbonate, dolomite, calcium sulfate dihydrate, and mixtures of at least two of these substances.

11. The method according to claim 9 wherein the particle size of at least 50% by weight of the particles of the calcium salt as determined by sieve analysis is less than 1 mm.

12. The method according to claim 11 wherein the particle size of at least 50% by weight of the particles of the calcium salt as determined by sieve analysis is less than 100 μm.

13. The method according to claim 12 wherein the particle size of at least 50% by weight of the particles of the calcium salt as determined by sieve analysis is less than 64 μm.

14. The method according to claim 9 further comprising the procedural step of
(iv) adding at least one additive to the particles of the calcium salt, the saturated fatty acid ester (a), the saturated fatty acid ester (b) or a mixture of at least two of these components.

15. The method according to claim 9 wherein appropriate relative quantities of the components are being contacted with each other to allow a pasty composition to be obtained that contains
(α1) 50 to 80% by weight of the particles of a calcium salt;
(α2) 0.1 to 25% by weight of the saturated fatty acid ester (a);
(α3) 15 to 40% by weight of the saturated fatty acid ester (b); and
(α4) 0 to 10% by weight of an additive;
whereby the amounts of components (α1) add up to (α4) 100% by weight.

16. A pasty composition, obtainable through a method according to claim 9 .

Assignees

• Heraeus Medical Gmbh

Inventors

• Vogt Sebastian

Classifications

• A61L27/12 Primary

  Phosphorus-containing materials, e.g. apatite · CPC title

• A61L24/02

  containing inorganic materials · CPC title

• A61L27/50 Primary

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61L27/025

  Other specific inorganic materials not covered by A61L27/04 - A61L27/12 · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title