Compositions and methods for accurately identifying mutations
US-2024409996-A1 · Dec 12, 2024 · US
Identification of 5-methyl-C in nucleic acid templates
US9175348B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9175348-B2 |
| Application number | US-201313868661-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 23, 2013 |
| Priority date | Apr 24, 2012 |
| Publication date | Nov 3, 2015 |
| Grant date | Nov 3, 2015 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
A method for identifying a 5-MeC in a template nucleic is provided. The method comprises providing a template having 5-MeC, converting the 5-MeC into a further modification selected from 5-caC and 5-FC. The converted template is then sequenced, and a change in sequencing is detected that is indicative of the further modification, allowing for identifying the 5-MeC in the template nucleic acid.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for identifying a 5-methylcytosine (5-MeC) in a template nucleic acid, the method comprising: a) providing a template nucleic acid comprising the 5-MeC; b) converting the 5-MeC into a modified base by treating the template nucleic acid with a Tet protein, wherein the modified base is selected from 5-carboxylcytosine (5-caC) and 5-formylcytosine (5-fC), thereby generating a modified template nucleic acid; c) sequencing the modified template nucle…
Assignees
Inventors
Classifications
Chemistry & Metallurgy · mapped topic
- C12Q1/6827Primary
Chemistry & Metallurgy · mapped topic
- C12Q1/6883Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Patent family
Related publications grouped by family.
External sources
Next steps
Free tools are coming soon. Tell us what you want to track and we'll notify you.
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9175348B2 cover?
- A method for identifying a 5-MeC in a template nucleic is provided. The method comprises providing a template having 5-MeC, converting the 5-MeC into a further modification selected from 5-caC and 5-FC. The converted template is then sequenced, and a change in sequencing is detected that is indicative of the further modification, allowing for identifying the 5-MeC in the template nucleic acid.
- Who is the assignee on this patent?
- Pacific Biosciences California, Univ Chicago
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/6827. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).