Pyridazinedione-based heterobicyclic covalent linkers and methods and applications thereof
US-2024425465-A1 · Dec 26, 2024 · US
US9174992B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9174992-B2 |
| Application number | US-201313780557-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 28, 2013 |
| Priority date | Feb 29, 2012 |
| Publication date | Nov 3, 2015 |
| Grant date | Nov 3, 2015 |
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Heterobicyclic compounds of Formula (I): or a pharmaceutically-acceptable salt, tautomer, or stereoisomer thereof, as defined in the specification, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, Huntington's Disease, and the like.
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What is claimed is: 1. A compound of Formula (I): or a pharmaceutically-acceptable salt, tautomer, or stereoisomer thereof, wherein: each p and q is independently 1; wherein the sum of p and q is 2; m is 0, 1, 2, 3, or 4; A is a 9- to 10-membered heterocyclic ring having the formula:…
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