TARGET-BASED METHOD FOR HIGH-THROUGHPUT AND SUBCLASS SPECIFIC IgG GLYCAN PROFILING IN HUMAN PLASMA
US-2024353417-A1 · Oct 24, 2024 · US
Comparison of protein samples
US9170262B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9170262-B2 |
| Application number | US-201113161907-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 16, 2011 |
| Priority date | Jun 16, 2010 |
| Publication date | Oct 27, 2015 |
| Grant date | Oct 27, 2015 |
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Abstract
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Methods of qualitatively and/or quantitatively detecting the presence of mutations, modifications or impurities in a protein sample are provided. The methods utilize isotopically labeled variants of amino acids incorporated into proteins prior to protein digest to enable comparisons of two protein samples in bottom-up liquid chromatography.
First claim
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What is claimed is: 1. A method of characterizing a protein sample, the method comprising: (i) providing a sample of a first protein, having a known amino acid sequence, wherein at least one amino acid in the first protein is replaced with an isotopically labeled amino acid comprising at least one heavy isotope; (ii) providing a sample of a second, unlabeled protein comprising an unlabeled amino acid corresponding to the isotopically labeled variant in the first protein; (iii)…
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- G01N33/6848Primary
Physics · mapped topic
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- What does patent US9170262B2 cover?
- Methods of qualitatively and/or quantitatively detecting the presence of mutations, modifications or impurities in a protein sample are provided. The methods utilize isotopically labeled variants of amino acids incorporated into proteins prior to protein digest to enable comparisons of two protein samples in bottom-up liquid chromatography.
- Who is the assignee on this patent?
- Manuilov Anton V, Lee David H, Abbvie Inc
- What technology area does this patent fall under?
- Primary CPC classification G01N33/6848. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Oct 27 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).