Designer circuit controlling diet-induced obesity
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Tetrary gene delivery system for gene therapy and methods of its use
US9168230B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9168230-B2 |
| Application number | US-201213477701-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 22, 2012 |
| Priority date | May 26, 2011 |
| Publication date | Oct 27, 2015 |
| Grant date | Oct 27, 2015 |
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Abstract
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Delivery systems and their methods of formation are generally provided. The delivery system can protect a delivery molecule (e.g., DNA/RNA) and deliver it into a cell via serum. In one embodiment, the method can include binding a delivery molecule with polyethylenimine such that an end of the delivery molecule is exposed; capping the end of the delivery molecule with a first biocompatible polymer to form a core; and encapsulating the core with a second biocompatible polymer. The resulting delivery system can include a delivery molecule bonded with polyethylenimine such that an end of the delivery molecule is exposed; a first biocompatible polymer electrostatically bonded to the end of the delivery molecule to form a core; and a second biocompatible polymer encapsulating the core.
First claim
Opening claim text (preview).
What is claimed: 1. A method of forming a delivery system, comprising: binding a DNA or RNA molecule with polyethylenimine such that an end of the DNA or RNA molecule is exposed, wherein the polyethyienimine has a positive electrostatic charge, and wherein the end of the DNA or RNA molecule has a negative electrostatic charge; thereafter, capping the end of the DNA or RNA molecule that is exposed with a crosslinked polyspermine, the crosslinked polyspermine having an N/P ratio g…
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Classifications
Human Necessities · mapped topic
- A61K9/5036Primary
Human Necessities · mapped topic
- A61K9/5184Primary
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US9168230B2 cover?
- Delivery systems and their methods of formation are generally provided. The delivery system can protect a delivery molecule (e.g., DNA/RNA) and deliver it into a cell via serum. In one embodiment, the method can include binding a delivery molecule with polyethylenimine such that an end of the delivery molecule is exposed; capping the end of the delivery molecule with a first biocompatible polym…
- Who is the assignee on this patent?
- Xu Peisheng, Bahadur K C Remant, Univ South Carolina
- What technology area does this patent fall under?
- Primary CPC classification A61K9/5036. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 27 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).