Plasma cytochrome c as a biomarker for mitochondrial toxicity during antiretroviral therapy
US-2015346213-A1 · Dec 3, 2015 · US
US9164094B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9164094-B2 |
| Application number | US-201213452344-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 20, 2012 |
| Priority date | Oct 22, 2009 |
| Publication date | Oct 20, 2015 |
| Grant date | Oct 20, 2015 |
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The invention relates to expression profiles of HIV-specific T-cells and their methods of use, including but not limited to treatment of HIV, increasing T-cell function and/or survival in HIV infected subjects, monitoring HIV disease progression and classifying HIV infected subjects as controllers or chronic progressors.
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What is claimed: 1. A method of classifying an immune response in an individual infected with HIV comprising: obtaining a biological sample from an individual infected with HIV; determining an expression profile of HIV specific T-cells from said HIV-infected individual by determining hybridization of a nucleic acid in said sample to a probe on a microarray, wherein said expression profile comprises an expression level of at least two genes selected from those presented in FIG.…
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