Fibrous mats containing chitosan nanofibers

Patent metadata

Field	Value
Publication number	US-9163338-B2
Application number	US-59811208-A
Country	US
Kind code	B2
Filing date	Apr 11, 2008
Priority date	Apr 11, 2007
Publication date	Oct 20, 2015
Grant date	Oct 20, 2015

Abstract

The invention relate to fibrous mats comprising chitosan nanofibers and, optionally, at least one filler material, at least one additive, or both. The invention also relates to methods of making same, and devices that include a fibrous mat comprising chitosan nanofibers.

First claim

What is claimed:

1. A fibrous mat comprising chitosan nanofibers having an average diameter of about 50 to about 120 nanometers, wherein said fibrous mat is substantially free of fibers of polyethylene oxide or fibers of poly(vinyl alchohol), and wherein said chitosan nanofibers are electrospun from chitosan.

2. The fibrous mat according to claim 1 further comprising a filler material.

3. The fibrous mat of claim 2 , wherein the at least one filler material is clay, diatomaceous earth, calcium carbonate, metakaolinite, limestone, carbon black, or mixtures thereof.

4. The fibrous mat of claim 2 comprising about 0.1% to about 60% by weight of said filler material.

5. The fibrous mat of claim 1 , wherein the chitosan is cross-linked after fiber production.

6. The fibrous mat of claim 5 , wherein the chitosan is cross-linked using glutaraldehyde vapor.

7. The fibrous mat of claim 1 , wherein the chitosan is cross-linked during fiber production.

8. The fibrous mat according to claim 1 further comprising at least one additive.

9. The fibrous mat of claim 8 , wherein the at least one additive comprises a dye, polymer, particle, nanoparticle, organic molecule, or any combination thereof.

10. The fibrous mat of claim 9 , wherein the dye is nile red or phthalocynanine green.

11. The fibrous mat of claim 9 , wherein the polymer comprises hyaluronic acid, alginate, chitin, carboxymethylated chitosan, or any combination thereof.

12. The fibrous mat of claim 9 , wherein the at least one additive comprises particles or nanoparticles comprising manganese, gold, silver, copper, platinum, palladium, or any combination thereof.

13. The fibrous mat of claim 9 , wherein the organic molecule is a cross-linker, a protein, or an enzyme.

14. The fibrous mat of claim 13 , wherein the organic molecule comprises a cross-linker, and the cross-linker comprises glutaraldehyde.

15. The fibrous mat of claim 8 wherein the nanofibers consist essentially of chitosan.

16. The fibrous mat of claim 8 further comprising at least one filler material, wherein the filler material is clay, diatomaceous earth, calcium carbonate, metakaolinite, limestone, carbon black, or mixtures thereof.

17. The fibrous mat according to claim 16 comprising about 0.1% to about 60% by weight of said filler material.

18. A filter comprising a fibrous mat according to claim 8 .

19. A scaffold comprising a fibrous mat according to claim 8 .

20. The fibrous mat according to claim 1 wherein said chitosan nanofibers are electrospun from chitosan in the presence of a tri-halo carboxylic acid solvent.

21. A filter comprising a fibrous mat according to claim 1 .

22. A scaffold comprising a fibrous mat according to claim 1 .

Assignees

• Schauer Caroline L
• Schiffman Jessica D
• Univ Drexel

Inventors

• Schauer Caroline L
• Schiffman Jessica D

Classifications

• A61L27/20

  Polysaccharides · CPC title

• D01D5/0038

  the fibre formed by solvent evaporation, i.e. dry electro-spinning · CPC title

• D01F9/00 Primary

  Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments · CPC title

• B01D2239/025

  comprising nanofibres · CPC title

• Y10T428/249921

  Web or sheet containing structurally defined element or component · CPC title