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Anti-OX40 antibodies and methods of treating cancer
US9163085B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9163085-B2 |
| Application number | US-201214240535-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 9, 2012 |
| Priority date | Aug 23, 2010 |
| Publication date | Oct 20, 2015 |
| Grant date | Oct 20, 2015 |
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Abstract
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Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.
First claim
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We claim: 1. An isolated antibody or an antigen-binding portion thereof which binds to and agonizes OX40 comprising: (a) a heavy chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO: 25; (b) a heavy chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO: 26; (c) a heavy chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO. 27; (d) a light chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO. 32; (…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9163085B2 cover?
- Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating rece…
- Who is the assignee on this patent?
- Liu Yong-Jun, Voo Kui Shin, Bover Laura, and 4 more
- What technology area does this patent fall under?
- Primary CPC classification C07K16/2878. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 20 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).