Gene therapy for recessive dystrophic epidermolysis bullosa using genetically corrected autologous keratinocytes
US-12173314-B2 · Dec 24, 2024 · US
US9162012B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9162012-B2 |
| Application number | US-201414310804-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 20, 2014 |
| Priority date | Jun 15, 2007 |
| Publication date | Oct 20, 2015 |
| Grant date | Oct 20, 2015 |
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Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
Opening claim text (preview).
The invention claimed is: 1. An osteoinductive composition, the composition comprising: heat and gaseous supercritical carbon dioxide treated surface demineralized bone particles, the bone particles ranging from approximately 1 mm to approximately 4 mm in their longest dimension, and being approximately 10 to approximately 50% demineralized; demineralized bone matrix; and a delivery vehicle, and the bone particles are surface demineralized at a depth of at least 50 microns.…
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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