Bone matrix compositions and methods

US9162012B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9162012-B2
Application numberUS-201414310804-A
CountryUS
Kind codeB2
Filing dateJun 20, 2014
Priority dateJun 15, 2007
Publication dateOct 20, 2015
Grant dateOct 20, 2015

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  2. Abstract

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  5. First independent claim

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Abstract

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Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.

First claim

Opening claim text (preview).

The invention claimed is: 1. An osteoinductive composition, the composition comprising: heat and gaseous supercritical carbon dioxide treated surface demineralized bone particles, the bone particles ranging from approximately 1 mm to approximately 4 mm in their longest dimension, and being approximately 10 to approximately 50% demineralized; demineralized bone matrix; and a delivery vehicle, and the bone particles are surface demineralized at a depth of at least 50 microns.…

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What does patent US9162012B2 cover?
Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-induci…
Who is the assignee on this patent?
Warsaw Orthopedic Inc
What technology area does this patent fall under?
Primary CPC classification A61L27/3695. Mapped technology areas include Human Necessities.
When was this patent published?
Publication date Tue Oct 20 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).