Oligosaccharide mixture and food product comprising this mixture, especially infant formula

Patent metadata

Field	Value
Publication number	US-9161563-B2
Application number	US-201113988967-A
Country	US
Kind code	B2
Filing date	Nov 21, 2011
Priority date	Nov 23, 2010
Publication date	Oct 20, 2015
Grant date	Oct 20, 2015

Abstract

The invention discloses an oligosaccharide mixture comprising 5-70 wt % of at least one N-acetylated oligosaccharide, 5-90 wt % of at least one neutral oligosaccharide, 2-50 wt % of at least one sialylated oligosaccharide, and/or 5-70 wt % of at least one fucosylated oligosaccharide. The invention also discloses a food product, especially an infant formula, comprising said oligosaccharide mixture.

First claim

The invention claimed is:

1. A food product comprising: hydrolyzed proteins; and an oligosaccharide mixture which comprises:
5-70 wt % of at least one N-acetylated oligosaccharide selected from the group consisting of N-acetyl-galactosaminyl-lactose and galactosyl-N-acetyl-galactosaminyl-lactose,
5-90 wt % of at least one galacto-oligosaccharide selected from the group consisting of Galβ1,6Gal, Galβ1,6Galβ1,4Glc, Galβ1,6Galβ1,6Glc, Galβ1,3Galβ1,3Glc, Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,6Galβ1,4Glc, Galβ1,6Galβ1,3Galβ1,4Glc, Galβ1,3Galβ1,6Galβ1,4Glc, Galβ1,3Galβ1,3Galβ1,4Glc, Galβ1,4Galβ1,4Glc and Galβ1,4Galβ1,4Galβ1,4Glc,
2-50 wt % of at least one sialylated oligosaccharide selected from the group consisting of 3′-sialyllactose and 6′-sialyllactose; and
2-70 wt % of at least one fucosylated oligosaccharide selected from the group consisting of 2′-fucosyllactose, 3-fucosyllactose, difucosyllactose, lacto-N-fucopentaoses, lacto-N-difucohexaose I, monofucosyllacto-N-hexaose, Difucosyllacto-N-hexaose I and Difucosyllacto-N-neohexaose II.

2. A food product according to claim 1 comprising a protein source, a fat source, and a carbohydrate source, wherein the protein source comprises the hydrolyzed proteins.

3. The food product according to claim 1 , which is selected from the group consisting of a starter infant formula, an infant formula, a baby food, an infant cereal composition, a follow-up formula and a growing-up milk.

4. The food product according to claim 1 , wherein the extent of hydrolysis of the hydrolysed proteins is between 50 and 100 of NPN/TN %.

5. The food product according to claim 1 , wherein a trinitrobenzenesulfonic acid reactive Nitrogen % that reacts with amino (lysine) N/TN of the hydrolysed proteins is from 8-15%.

6. A method for preventing and reducing the risk of food allergies and related food allergy effects on health of an individual, the method comprising:
administering to the individual oligosaccharide mixture which comprises 5-70 wt % of at least one N-acetylated oligosaccharide selected from the group consisting of N-acetyl-galactosaminyl-lactose and galactosyl-N-acetyl-galactosaminyl-lactose, 5-90 wt % of at least one galacto-oligosaccharide selected from the group consisting of Galβ1,6Gal, Galβ1,6Galβ1,4Glc, Galβ1,6Galβ1,6Glc, Galβ1,3Galβ1,3Glc, Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,6Galβ1,4Glc, Galβ1,6Galβ1,3Galβ1,4Glc, Galβ1,3Galβ1,6Galβ1,4Glc, Galβ1,3Galβ1,3Galβ1,4Glc, Galβ1,4Galβ1,4Glc and Galβ1,4Galβ1,4Galβ1,4Glc, 2-50 wt % of at least one sialylated oligosaccharide selected from the group consisting of 3′-sialyllactose and 6′-sialyllactose; and 2-70 wt % of at least one fucosylated oligosaccharide selected from the group consisting of 2′-fucosyllactose, 3-fucosyllactose, difucosyllactose, lacto-N-fucopentaoses, lacto-N-difucohexaose I, monofucosyllacto-N-hexaose, Difucosyllacto-N-hexaose I and Difucosyllacto-N-neohexaose II.

7. The method according to claim 6 , wherein the effects are selected from the group consisting of (i) skin effects, atopic dermatitis, rash, or redness; (ii) effects on the immune system or inflammation status; or (iii) effects on the gastro-intestinal system.

8. The method according to claim 6 , wherein the composition provides enhancement of the oral tolerance to allergens.

9. The food product according to claim 1 , wherein the food product comprises at least one probiotic bacterial strain.

10. A method for reducing the severity and reducing the occurrence of food allergies and related food allergy effects on health, the method comprising:
administering to an individual an oligosaccharide mixture comprising 5-70 wt % of at least one N-acetylated oligosaccharide selected from the group consisting of N-acetyl-galactosaminyl-lactose and galactosyl-N-acetyl-galactosaminyl-lactose, 5-90 wt % of at least one galacto-oligosaccharide selected from the group consisting of Galβ1,6Gal, Galβ1,6Galβ1,4Glc, Galβ1,6Galβ1,6Glc, Galβ1,3Galβ1,3Glc, Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,6Galβ1,4Glc, Galβ1,6Galβ1,3Galβ1,4Glc, Galβ1,3Galβ1,6Galβ1,4Glc, Galβ1,3Galβ1,3Galβ1,4Glc, Galβ1,4Galβ1,4Glc and Galβ1,4Galβ1,4Galβ1,4Glc, 2-50 wt % of at least one sialylated oligosaccharide selected from the group consisting of 3′-sialyllactose and 6′-sialyllactose, and/or 5-70 wt % of at least one fucosylated oligosaccharide selected from the group consisting of 2′-fucosyllactose, 3-fucosullactose, difucosyllactose, lacto-N-fucopentaoses, lacto-N-difucohexaose I, monofucosyllacto-N-hexaose, Difucosyllacto-N-hexaose I and Difucosyllacto-N-neohexaose II, as a synthetic nutritional composition.

11. A method for the enhancement of oral tolerance to allergens, the method comprising:
administering to an individual a food product comprising 5-70 wt % of at least one N-acetylated oligosaccharide selected from the group consisting of N-acetyl-galactosaminyl-lactose and galactosyl-N-acetyl-galactosaminyl-lactose, 5-90 wt % of at least one galacto-oligosaccharide selected from the group consisting of Galβ1,6Gal, Galβ1,6Galβ1,4Glc, Galβ1,6Galβ1,6Glc, Galβ1,3Galβ1,3Glc, Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,6Galβ1,4Glc, Galβ1,6Galβ1,3Galβ1,4Glc, Galβ1,3Galβ1,6Galβ1,4Glc, Galβ1,3Galβ1,3Galβ1,4Glc, Galβ1,4Galβ1,4Glc and Galβ1,4Galβ1,4Galβ1,4Glc, 2-50 wt % of at least one sialylated oligosaccharide selected from the group consisting of 3′-sialyllactose and 6′-sialyllactose, and/or 5-70 wt % of at least one fucosylated oligosaccharide selected from the group comprising consisting of 2′-fucosyllactose, 3-fucosyllactose, difucosyllactose, lacto-N-fucopentaoses, lacto-N-difucohexaose I, monofucosyllacto-N-hexaose, Difucosyllacto-N-hexaose I and Difucosyllacto-N-neohexaose II, as a synthetic nutritional composition.

12. The method according to claims 10 , wherein the food product is a supplement.

13. The method according to claim 10 wherein the food product comprises fully hydrolyzed and/or partially hydrolyzed proteins.

14. The method according to claim 11 , wherein the food product is a supplement.

15. The method according to claim 11 wherein the food product comprises fully hydrolyzed and/or partially hydrolyzed proteins.

Assignees

• Sprenger Norbert
• Neeser Jean-Richard
• Nestec Sa

Inventors

• Sprenger Norbert
• Neeser Jean-Richard

Classifications

• A61P37/00

  Drugs for immunological or allergic disorders · CPC title

• A23L33/135

  Bacteria or derivatives thereof, e.g. probiotics · CPC title

• A61K31/716

  Glucans · CPC title

• A61K31/702 Primary

  Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages · CPC title

• C07H13/04

  having the esterifying carboxyl radicals attached to acyclic carbon atoms · CPC title