Contrast enhancement agents and method of use thereof

Patent metadata

Field	Value
Publication number	US-9155804-B2
Application number	US-201213626942-A
Country	US
Kind code	B2
Filing date	Sep 26, 2012
Priority date	Sep 26, 2012
Publication date	Oct 13, 2015
Grant date	Oct 13, 2015

Abstract

A contrast agent composition and a method of diagnostic imaging are provided. The composition comprises a pharmaceutically acceptable carrier and a metal-complex comprising a ligand having structure (XXX):

wherein R 1 , R 2 , R 3 , R 7 , R 8 , R′ 1 , R′ 2 , R′ 3 , R 7 ′ and R 8 ′ are selected form hydrogen, a protected C 1 -C 3 hydroxyalkyl group, or a C 1 -C 3 alkyl group; R 4 , R′ 4 are selected from a hydrogen, a hydroxyl, a protected hydroxyl group, a protected C 1 -C 3 hydroxyalkyl group, a C 1 -C 3 alkyl group; n is an integer between 0 and 4; R 5 , R′ 5 are selected from a hydrogen, a protecting group comprising C 1 -C 30 aliphatic radicals, C 3 -C 30 cycloaliphatic radicals, C 2 -C 30 aromatic radicals, m is an integer between 1 and 10; at least one of R 7 and R′ 7 is acidic groups or protected acidic groups; Y comprises a protein or peptide moiety, a particle, a micelle, a liposome, an organic molecule, oligomer, polymer or a hydrophilic moiety.

First claim

What is claimed is:

1. A contrast agent composition, comprising:
a pharmaceutically acceptable carrier or excipient; and
a metal-complex derived from a metal and a ligand having a structure (XXXI):

wherein R 1 , R 2 , R 3 , R′ 1 , R′ 2 , and R′ 3 , are independently at each occurrence hydrogen, or a C 1 -C 3 alkyl group;
R 4 and R′ 4 are independently at each…

Assignees

• Gen Electric

Inventors

• Grimmond Brian James
• Rishel Michael James
• Roberts Jeannette Christine

Classifications

• A61K49/126 Primary

  Human Necessities · mapped topic