Scaffold-kinase interaction blockades and uses thereof in treating cancer

US9155774B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9155774-B2
Application numberUS-201214123953-A
CountryUS
Kind codeB2
Filing dateApr 5, 2012
Priority dateJun 8, 2011
Publication dateOct 13, 2015
Grant dateOct 13, 2015

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Abstract

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Aspects of the invention include compositions and methods for inhibiting the interaction between scaffold proteins and kinases. These compositions and methods find a number of uses including, for example, suppressing tumor growth and metastasis and reducing tumor size and number in a mammal with cancer.

First claim

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That which is claimed is: 1. A method of inhibiting RAS pathway activity in a cell, the method comprising: adding to a cell in vitro an effective amount of an IQ motif containing GTPase activating protein I (IQGAP1) scaffold-kinase interaction blockade (SKIB) agent to block the interaction of a scaffold protein and a kinase thereby inhibiting RAS pathway activity in the cell, wherein the SKIB agent is an isolated IQGAP1 WW peptide or a nucleic acid encoding an isolated IQGAP1 WW p…

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What does patent US9155774B2 cover?
Aspects of the invention include compositions and methods for inhibiting the interaction between scaffold proteins and kinases. These compositions and methods find a number of uses including, for example, suppressing tumor growth and metastasis and reducing tumor size and number in a mammal with cancer.
Who is the assignee on this patent?
Jameson Katherine Laroque, Khavari Paul A, Univ Leland Stanford Junior
What technology area does this patent fall under?
Primary CPC classification A61K38/005. Mapped technology areas include Human Necessities.
When was this patent published?
Publication date Tue Oct 13 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).