Self-assembled nanoparticle and use thereof for anti- angiogenesis
US-2024033316-A1 · Feb 1, 2024 · US
US9155774B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9155774-B2 |
| Application number | US-201214123953-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 5, 2012 |
| Priority date | Jun 8, 2011 |
| Publication date | Oct 13, 2015 |
| Grant date | Oct 13, 2015 |
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Aspects of the invention include compositions and methods for inhibiting the interaction between scaffold proteins and kinases. These compositions and methods find a number of uses including, for example, suppressing tumor growth and metastasis and reducing tumor size and number in a mammal with cancer.
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That which is claimed is: 1. A method of inhibiting RAS pathway activity in a cell, the method comprising: adding to a cell in vitro an effective amount of an IQ motif containing GTPase activating protein I (IQGAP1) scaffold-kinase interaction blockade (SKIB) agent to block the interaction of a scaffold protein and a kinase thereby inhibiting RAS pathway activity in the cell, wherein the SKIB agent is an isolated IQGAP1 WW peptide or a nucleic acid encoding an isolated IQGAP1 WW p…
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