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Compositions comprising an aromatic alcohol and a TRPV-1 antagonist, and uses thereof
US9155714B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9155714-B2 |
| Application number | US-201414278007-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 15, 2014 |
| Priority date | Jun 6, 2013 |
| Publication date | Oct 13, 2015 |
| Grant date | Oct 13, 2015 |
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- Title
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Abstract
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A topical composition providing reduced irritation that contains aromatic alcohols such as phenoxyethanol and a TRPV-1 antagonist is described. The composition is substantially free of parabens. The composition may be used for example for cleansing the skin.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of reducing irritation induced by topical application of an aromatic alcohol having the formula: wherein X is an oxygen atom or absent and Y is C1-C2 alkyl; said method comprising topically applying said aromatic alcohol with a TRPV-1 antagonist. 2. The method of claim 1 , wherein said aromatic alcohol is selected from the group consisting of phenoxyethanol, benzyl alcohol, phenethyl alcohol, and mixtures thereof. 3. The method of claim 1 , wherein the aromatic alcohol is phenoxyethanol. 4. The method of claim 1 , wherein said TRPV-1 antagonist inhibits the calcium flux of the aromatic alcohol by at least about 12% as measured by the Calcium Flux Test. 5. The method of claim 1 , wherein said TRPV-1 antagonist is 4-tertiary butyl cyclohexanol.
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Classifications
Derivatives containing from 2 to 10 oxyalkylene groups · CPC title
- A61K31/085Primary
having an ether linkage to aromatic ring nuclear carbon · CPC title
with one nitrogen as the only hetero atom · CPC title
having 6-membered rings or their condensed derivatives, e.g. coumarin · CPC title
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates · CPC title
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Frequently asked questions
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- What does patent US9155714B2 cover?
- A topical composition providing reduced irritation that contains aromatic alcohols such as phenoxyethanol and a TRPV-1 antagonist is described. The composition is substantially free of parabens. The composition may be used for example for cleansing the skin.
- Who is the assignee on this patent?
- Johnson & Johnson Consumer Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/085. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 13 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).