Direct light differential measurement system
US-2024423517-A1 · Dec 26, 2024 · US
US9155497B1 · US · B1
| Field | Value |
|---|---|
| Publication number | US-9155497-B1 |
| Application number | US-201213487933-A |
| Country | US |
| Kind code | B1 |
| Filing date | Jun 4, 2012 |
| Priority date | Jun 2, 2011 |
| Publication date | Oct 13, 2015 |
| Grant date | Oct 13, 2015 |
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The invention provides a quantum dot (QD) modified optical fiber-based biosensor which characterizes matrix metalloproteinase (MMP) enzyme activity at pain signaling sites in the central nervous system (CNS) in vivo. Related systems and peptide biomarker screening methods are also provided.
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What is claimed is: 1. A quantum dot (QD) modified optical fiber-based biosensor system adapted for evaluation of metalloproteinase (MMP) enzyme activity at pain signaling sites in the central nervous system (CNS), said biosensor system comprising: (a) a multimode silica optical fiber comprising one or more quantum dots that (1) are bioconjugated on their surface to one or more peptides having an affinity for said metalloproteinase (MMP) enzyme, and (2) that are tethered to an ins…
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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