Humanized IL-15 animals

US9155290B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9155290-B2
Application numberUS-201414514454-A
CountryUS
Kind codeB2
Filing dateOct 15, 2014
Priority dateOct 15, 2013
Publication dateOct 13, 2015
Grant dateOct 13, 2015

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Abstract

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Genetically modified non-human animals comprising a humanized interleukin-15 (IL-15) gene. Cells, embryos, and non-human animals comprising a human IL-15 gene. Rodents that express humanized or human IL-15 protein.

First claim

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What is claimed is: 1. A genetically modified mouse whose genome comprises a replacement at an endogenous mouse IL-15 locus of a mouse genomic segment comprising sequences of mouse exons 3, 4, 5 and 6 coding for a mature mouse IL-15 polypeptide with a human genomic segment comprising human IL-15 exons coding for a mature human IL-15 polypeptide to form a humanized IL-15 gene, wherein the human IL-15 exons in said human genomic segment consist of human exons 3, 4, 5 and 6, wherein…

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What does patent US9155290B2 cover?
Genetically modified non-human animals comprising a humanized interleukin-15 (IL-15) gene. Cells, embryos, and non-human animals comprising a human IL-15 gene. Rodents that express humanized or human IL-15 protein.
Who is the assignee on this patent?
Regeneron Pharma
What technology area does this patent fall under?
Primary CPC classification A01K67/0278. Mapped technology areas include Human Necessities.
When was this patent published?
Publication date Tue Oct 13 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).