Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes
US-2024130341-A1 · Apr 25, 2024 · US
US9155290B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9155290-B2 |
| Application number | US-201414514454-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 15, 2014 |
| Priority date | Oct 15, 2013 |
| Publication date | Oct 13, 2015 |
| Grant date | Oct 13, 2015 |
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Genetically modified non-human animals comprising a humanized interleukin-15 (IL-15) gene. Cells, embryos, and non-human animals comprising a human IL-15 gene. Rodents that express humanized or human IL-15 protein.
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What is claimed is: 1. A genetically modified mouse whose genome comprises a replacement at an endogenous mouse IL-15 locus of a mouse genomic segment comprising sequences of mouse exons 3, 4, 5 and 6 coding for a mature mouse IL-15 polypeptide with a human genomic segment comprising human IL-15 exons coding for a mature human IL-15 polypeptide to form a humanized IL-15 gene, wherein the human IL-15 exons in said human genomic segment consist of human exons 3, 4, 5 and 6, wherein…
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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