Nucleic acid detection
US-2024392360-A1 · Nov 28, 2024 · US
Determination of the integrity of RNA
US9150909B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9150909-B2 |
| Application number | US-54822609-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 26, 2009 |
| Priority date | Aug 29, 2008 |
| Publication date | Oct 6, 2015 |
| Grant date | Oct 6, 2015 |
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Abstract
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Methods, systems, and apparatus make a determination of a level of integrity of a sample of biomolecules. For example, the determination of the integrity of RNA in a sample may be done in a fast and reproducible manner, such that the user can be assured of accuracy of a test (e.g. quantitative polymerase chain reaction qPCR) on the sample and compare results of different samples. The determination of integrity of an RNA sample is performed by comparing a size profile to reference size profiles (degradation standards) obtained from degradation over different lengths of times. As the reference scale of the level of integrity is derived from the actual degradation that occurs in a sample, high accuracy, reproducibility, and efficiency is provided.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of improving accuracy and reproducibility of determining a level of integrity of a sample of ribonucleic acid (RNA) and/or deoxyribonucleic acid (DNA) molecules, the method comprising: receiving a first size profile of the sample of the RNA and/or DNA molecules, wherein a size profile provides a measure of a distribution of values of at least one dimension of the RNA and/or DNA molecules, in the sample, the at least one dimension including length a…
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Chemistry & Metallurgy · mapped topic
- C12Q1/6816Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
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Frequently asked questions
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- What does patent US9150909B2 cover?
- Methods, systems, and apparatus make a determination of a level of integrity of a sample of biomolecules. For example, the determination of the integrity of RNA in a sample may be done in a fast and reproducible manner, such that the user can be assured of accuracy of a test (e.g. quantitative polymerase chain reaction qPCR) on the sample and compare results of different samples. The determinat…
- Who is the assignee on this patent?
- Denisov Vladimir, Bio Rad Laboratories
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/6816. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 06 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).