Methods and Compositions for Generating Bioactive Assemblies of Increased Complexity and Uses
US-2015374846-A1 · Dec 31, 2015 · US
Conjugated factor VIII molecules
US9150848B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9150848-B2 |
| Application number | US-201414272726-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 8, 2014 |
| Priority date | Feb 27, 2008 |
| Publication date | Oct 6, 2015 |
| Grant date | Oct 6, 2015 |
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Abstract
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The present invention relates to B-domain truncated Factor VIII molecules with a modified circulatory half life, said molecule being covalently conjugated with a hydrophilic polymer. The invention furthermore relates to methods for obtaining such molecules as well as use of such molecules.
First claim
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What is claimed: 1. A B-domain truncated Factor VIII (FVIII) molecule, comprising: a heavy chain, a light chain, and a hydrophilic polymer; wherein (1) the heavy chain comprises a linker derived from the B-domain of a full-length FVIII molecule (SEQ ID NO:1) comprising a protease recognition site, (2) the hydrophilic polymer is covalently conjugated to the linker at Ser750 amino acid residue numbered relative to SEQ ID NO:1 via an O-linked oligosaccharide, (3) the length of the lin…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US9150848B2 cover?
- The present invention relates to B-domain truncated Factor VIII molecules with a modified circulatory half life, said molecule being covalently conjugated with a hydrophilic polymer. The invention furthermore relates to methods for obtaining such molecules as well as use of such molecules.
- Who is the assignee on this patent?
- Novo Nordisk As
- What technology area does this patent fall under?
- Primary CPC classification C12N9/96. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 06 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).