Compositions and methods for targeted delivery to cells
US-2024390271-A1 · Nov 28, 2024 · US
Isolated bacterial strain of Achromobacter sp. MTCC 5605 and a highly enantioselective epoxide hydrolase isolated therefrom
US9150840B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9150840-B2 |
| Application number | US-201214000730-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 27, 2012 |
| Priority date | Aug 26, 2011 |
| Publication date | Oct 6, 2015 |
| Grant date | Oct 6, 2015 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
The present invention relates to a novel epoxide hydrolase enzyme which aims to achieve a high degree of resolution towards a broader range of substrates with high enantioselectivity and yields with minimal product inhibition. The invention further relates to a new bacterial strain Achromobacter sp. MTCC 5605 isolated from a petroleum-contaminated sludge sample, capable of producing the said enzyme. It is notable that the enzyme can be used as whole bacterial cell preparation, which allows continuous hydrolysis of substrates at even higher concentration and have an advantage of being recycled. The invention further relates to a process for the hydrolysis of different aryl epoxides which are potential synthons of intermediates for the synthesis of chiral amino alcohols and bioactive compounds like β-blockers.
First claim
Opening claim text (preview).
We claim: 1. An aqueous composition of an isolated enantioselective epoxide hydrolase from Achromobacter MTCC 5605 having a molecular weight of 95 KDa, said enantiomeric epoxide hydrolase being active in the pH range of 5 to 11 and at a temperature ranging from 30° to 50° C., exhibiting hydrolysis of racemic aryl epoxides with >99% ee s at a substrate concentration up to 500 mM, yielding up to 42% of 100% optically pure aryl epoxides with a final concentration of up to 209 mM wh…
Assignees
Inventors
Classifications
- C12N9/14Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Patent family
Related publications grouped by family.
External sources
Next steps
Free tools are coming soon. Tell us what you want to track and we'll notify you.
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9150840B2 cover?
- The present invention relates to a novel epoxide hydrolase enzyme which aims to achieve a high degree of resolution towards a broader range of substrates with high enantioselectivity and yields with minimal product inhibition. The invention further relates to a new bacterial strain Achromobacter sp. MTCC 5605 isolated from a petroleum-contaminated sludge sample, capable of producing the said …
- Who is the assignee on this patent?
- Kamal Ahmed, Khanna Rohini, Kumar Chityal Ganesh, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C12N9/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 06 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).