METHODS AND SYSTEMS FOR FUNCTIONAL MATURATION OF iPSC AND ESC DERIVED CARDIOMYOCYTES
US-2024076619-A1 · Mar 7, 2024 · US
Cell training for local field stimulation
US9150832B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9150832-B2 |
| Application number | US-74562007-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 8, 2007 |
| Priority date | May 8, 2007 |
| Publication date | Oct 6, 2015 |
| Grant date | Oct 6, 2015 |
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Abstract
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A system is provided for stimulating one or more cells, wherein the stimulation is sub-threshold and may alter a transmembrane potential of the one or more cells. For some populations of cells it may be possible to affect the transmembrane potential to gain a therapeutic benefit. Cells of the sino-atrial node spontaneously depolarize predominantly due to the slow depolarization of transmembrane potential. The present system may provide sino-atrial cells with a local field stimulation that while not eliciting an action potential may nonetheless alter local transmembrane potential. Such alteration of transmembrane potential may permit an increase or decrease in a rate of depolarization, and hence modify heart rate.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of increasing a patient's heart rate, comprising: increasing a rate of diastolic depolarization of a cell colony to increase the patient's heart rate without spontaneously depolarizing the cell colony by applying a first local field stimulation (LFS) signal to the cell colony, the cell colony formed in vitro and implanted within a cardiac tissue of the patient, wherein the cell colony comprises cardiomyocytes derived from stem cells and contains a g…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US9150832B2 cover?
- A system is provided for stimulating one or more cells, wherein the stimulation is sub-threshold and may alter a transmembrane potential of the one or more cells. For some populations of cells it may be possible to affect the transmembrane potential to gain a therapeutic benefit. Cells of the sino-atrial node spontaneously depolarize predominantly due to the slow depolarization of transmembrane…
- Who is the assignee on this patent?
- Kenknight Bruce, Girouard Steven D, Cardiac Pacemakers Inc
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0657. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 06 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).