TARGET-BASED METHOD FOR HIGH-THROUGHPUT AND SUBCLASS SPECIFIC IgG GLYCAN PROFILING IN HUMAN PLASMA
US-2024353417-A1 · Oct 24, 2024 · US
Method for the production of variable domains
US9150640B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9150640-B2 |
| Application number | US-201013382561-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 9, 2010 |
| Priority date | Jul 10, 2009 |
| Publication date | Oct 6, 2015 |
| Grant date | Oct 6, 2015 |
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Abstract
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The present invention provides methods for the expression and/or production of variable domains with a C-terminal extension that can be used for coupling of the variable domain to one or more further groups, residues or moieties. In the method of the invention a yield of at least 80% of variable domains with a cysteine containing C-terminal extension is obtained. Also variable domains are provided and polypeptides comprising one or more variable domains obtainable by the methods of the present invention, as well as compounds that comprise such variable domains and/or polypeptides coupled to one or more groups, residues or moieties.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for the expression and/or production of a polypeptide comprising one or more immunoglobulin single variable domains linked to a C-terminal extension, said method comprising the steps of: a) maintaining a host under conditions that are such that said host expresses and/or produces the polypeptide; b) isolating and/or purifying the polypeptide from culture medium in which said host cell was cultivated; wherein the C-terminal extension is sel…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C07K16/00Primary
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US9150640B2 cover?
- The present invention provides methods for the expression and/or production of variable domains with a C-terminal extension that can be used for coupling of the variable domain to one or more further groups, residues or moieties. In the method of the invention a yield of at least 80% of variable domains with a cysteine containing C-terminal extension is obtained. Also variable domains are provi…
- Who is the assignee on this patent?
- Stals Hilde, De Brabandere Veronique, Schotte Peter, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07K16/00. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 06 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).