Pyridazinedione-based heterobicyclic covalent linkers and methods and applications thereof
US-2024425465-A1 · Dec 26, 2024 · US
US9150592B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9150592-B2 |
| Application number | US-201314135793-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 20, 2013 |
| Priority date | Dec 21, 2012 |
| Publication date | Oct 6, 2015 |
| Grant date | Oct 6, 2015 |
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The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
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What is claimed: 1. A compound represented by the following formula: or a pharmaceutically acceptable salt thereof, wherein: Ring 1 is heterocyclic or heteroaromatic; X is N, N(R 4′ ), C(R 4 ), or C(R 4 )(R 4 ); Y is N, N(R 4′ ), or C(R 4 ); Z is N(R 4′ ), C(R 4 )C(R 4 ) or C(R 4 ); A is N(R 3′ ) or C(R 3 )(R 3 ); G and J are independently S, C(R 1 )(R 2 ), or N(R 3…
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