Fluorescent sensors
US-2024019450-A1 · Jan 18, 2024 · US
Polyamine transporter selective compounds as anti cancer agents
US9150495B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9150495-B2 |
| Application number | US-201313953667-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 29, 2013 |
| Priority date | May 2, 2007 |
| Publication date | Oct 6, 2015 |
| Grant date | Oct 6, 2015 |
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- Title
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Abstract
Official abstract text for this publication.
Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel dimeric polyamines of the present invention demonstrate enhanced penetration into cells having an upregulated polyamine transport system, such as various types of cancer cells. The disclosed aromatic polyamine dimers provide highly efficient drugs for targeting cancer cells with active polyamine transporters.
First claim
Opening claim text (preview).
That which is claimed: 1. A method of treating a leukemia or melanoma cancer cell, the method comprising contacting the cell with a compound, conjugate or pharmaceutically acceptable salt thereof, wherein the compound is compound 7, and wherein the formula of compound 7 is 2. The method of claim 1 , wherein compound 7 is used in an effective amount to at least partially inhibit the polyamine transport system of the cell.
Assignees
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Classifications
- C07C211/31Primary
the six-membered aromatic ring being part of a condensed ring system formed by at least three rings · CPC title
Dyes with anthracene nucleus not condensed with any other ring · CPC title
Chemistry & Metallurgy · mapped topic
- C07C211/30Primary
the six-membered aromatic ring being part of a condensed ring system formed by two rings · CPC title
- C07C211/27Primary
having amino groups linked to the six-membered aromatic ring by saturated carbon chains · CPC title
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- What does patent US9150495B2 cover?
- Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel dimeric polyamines of the present invention demonstrate enhanced penetration into cells having an upregulated polyamine transport system, such as various types of cancer cells. The disclosed aromatic polya…
- Who is the assignee on this patent?
- Phanstiel Iv Otto, Univ Central Florida Res Found
- What technology area does this patent fall under?
- Primary CPC classification C07C211/31. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 06 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).