Process for preparing [(3-hydroxypyridine-2-carbonyl)amino]alkanoic acids, esters and amides
US-2015361043-A1 · Dec 17, 2015 · US
US9145366B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9145366-B2 |
| Application number | US-201213488554-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 5, 2012 |
| Priority date | Jun 6, 2011 |
| Publication date | Sep 29, 2015 |
| Grant date | Sep 29, 2015 |
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Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.
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What is claimed is: 1. A process for preparing a compound having the formula: wherein R 1 is chosen from: L is a linking unit having the formula: —(CR 7a R 7b ) n…
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