Cationic Lipid Compound and Composition for Delivery of Nucleic Acids and Use Thereof
US-2024360072-A1 · Oct 31, 2024 · US
Amino lipids and methods for the delivery of nucleic acids
US9139554B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9139554-B2 |
| Application number | US-200913123307-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 9, 2009 |
| Priority date | Oct 9, 2008 |
| Publication date | Sep 22, 2015 |
| Grant date | Sep 22, 2015 |
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Abstract
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The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
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The invention claimed is: 1. An amino lipid having the structure:
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- What does patent US9139554B2 cover?
- The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing ef…
- Who is the assignee on this patent?
- Hope Michael J, Semple Sean C, Chen Jianxin, and 6 more
- What technology area does this patent fall under?
- Primary CPC classification C07D317/28. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 22 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).