Heterocyclic modulators of lipid synthesis
US-2024400552-A1 · Dec 5, 2024 · US
US9119792B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9119792-B2 |
| Application number | US-201414445234-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 29, 2014 |
| Priority date | Apr 26, 2006 |
| Publication date | Sep 1, 2015 |
| Grant date | Sep 1, 2015 |
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Controlled-release preparations of oxcarbazepine and derivatives thereof for once-a-day administration are disclosed. The inventive compositions comprise solubility- and/or release enhancing agents to provide tailored drug release profiles, preferably sigmoidal release profiles. Methods of treatment comprising the inventive compositions are also disclosed.
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What is claimed is: 1. A pharmaceutical formulation for once-a-day administration of oxcarbazepine comprising multiple units, wherein each unit comprises a homogeneous mixture of: (a) oxcarbazepine; (b) 1-50%, by weight of the formulation, a matrix-forming polymer; (c) 1-80%, by weight of the formulation, at least one agent that enhances the solubility of oxcarbazepine; and (d) 10-90%, by weight of the formulation, at least one release promoting agent comprising a polymer ha…
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