Pyridazinedione-based heterobicyclic covalent linkers and methods and applications thereof
US-2024425465-A1 · Dec 26, 2024 · US
US9115136B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9115136-B2 |
| Application number | US-201314059868-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 22, 2013 |
| Priority date | Jan 30, 2009 |
| Publication date | Aug 25, 2015 |
| Grant date | Aug 25, 2015 |
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Provided is a novel compound represented by the following formula wherein each symbol is as defined in the specification, or a salt thereof, which has an angiotensin II receptor antagonistic activity and a peroxisome proliferator-activated receptor γ agonistic activity, and is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and/or metabolic diseases such as diabetes and the like, and the like.
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The invention claimed is: 1. A compound represented by the formula (I): wherein R 1 is a hydrogen atom, an optionally substituted C 1-6 alkyl, an optionally substituted 3- to 10-membered nonaromatic cyclic group or an optionally substituted 5- or 6-membered aromatic cyclic group, R 2 is an optionally substituted C 1-6 alkyl, R 3 is a hydrogen atom, a ha…
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