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Compounds and related methods for treatment of neurodegenerative diseases
US9114130B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9114130-B2 |
| Application number | US-201414271177-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 6, 2014 |
| Priority date | May 6, 2013 |
| Publication date | Aug 25, 2015 |
| Grant date | Aug 25, 2015 |
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- Title
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Abstract
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Aspects of the invention pertain to chemical compounds, therapeutic compositions, and methods for treating neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.
First claim
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We claim: 1. A method of reducing intracellular tau phosphorylation levels, wherein the method comprises administering, to cells comprising phosphorylated protein tau, an effective amount of compound A: 2. The method according to claim 1 , wherein the cells are in a subject in need of treatment for a neurodegenerative disease. 3. The method of claim 2 , wherein the neurodegenerative disease is a tauopathy. 4. The method of claim 3 , wherein the subject is a human. 5. The method of claim 4 , wherein the neurodegenerative disease is selected from Alzheimer's disease, Parkinson's disease, frontotemporal dementia, frontotemporal dementia with Parkinsonism, frontotemporal lobe dementia, pallidopontonigral degeneration, progressive supranuclear palsy, multiple system tauopathy, multiple system tauopathy with presenile dementia, Wilhelmsen-Lynch disease, Pick's disease, or Pick's disease-like dementia. 6. The method of claim 4 , wherein the neurodegenerative disease is Alzheimer's disease.
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Classifications
- A61K31/222Primary
with compounds having aromatic groups, e.g. dipivefrine, ibopamine · CPC title
- A61K31/395Primary
having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins · CPC title
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Frequently asked questions
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- What does patent US9114130B2 cover?
- Aspects of the invention pertain to chemical compounds, therapeutic compositions, and methods for treating neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.
- Who is the assignee on this patent?
- Jinwal Umesh, Baker Bill, Calcul Laurent, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K31/222. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 25 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).