Method for visualizing a lymph node and correspondingly embodied combined MR/PET apparatus

Patent metadata

Field	Value
Publication number	US-9113800-B2
Application number	US-201113187743-A
Country	US
Kind code	B2
Filing date	Jul 21, 2011
Priority date	Aug 6, 2010
Publication date	Aug 25, 2015
Grant date	Aug 25, 2015

Abstract

A method is disclosed for visualizing a lymph node in a volume section of an examination subject by way of a combined MR/PET apparatus and to a correspondingly embodied combined MR/PET apparatus. The method includes acquisition of PET data of the volume section by way of a positron emission detector in order to record on the basis of the PET data a metabolic activity per PET voxel within the predetermined volume section; acquisition of MR data of the volume section by way of a magnetic resonance system in order to record on the basis of the MR data a lymph-node-specific contrast per region of the predetermined volume section; and generation of an image as a function of the metabolic activity recorded per PET voxel and as a function of the lymph-node-specific contrast recorded per region, abnormal lymph nodes being visualized in the image as distinguishable from normal lymph nodes.

First claim

What is claimed is:

1. A method for visualizing lymph nodes in a volume section of an examination subject by way of a combined MR/PET apparatus, the method comprising:
acquiring PET data of the volume section, by way of a positron emission detector, to record, on the basis of the acquired PET data, a metabolic activity per PET voxel within the volume section;
acquiring MR data of the volume section, by way of a magnetic resonance system, to record, on the basis of the acquired MR data, a lymph-node-specific contrast per region of the volume section; and
generating an image as a function of metabolic activity recorded per PET voxel and as a function of the lymph-node-specific contrast recorded per region, abnormal lymph nodes being visualized in the image as being distinguishable from normal lymph nodes, wherein at least one of a plurality of predefined regions, each associated with a respective lymph node diagnosis, is identified in the image, the image generated to present said at least one identified predefined region as being visually distinguishable from a remainder of the image, wherein said plurality of predefined regions comprise of:
a region in which the lymph-node-specific contrast lies above a first set MR threshold value and in which the metabolic activity lies above a first set PET threshold value,
a region in which the lymph-node-specific contrast lies above the first set MR threshold value and in which the metabolic activity lies below a second set PET threshold value,
a region in which the lymph-node-specific contrast lies below a second set MR threshold value and in which the metabolic activity lies above the fn'st set PET threshold value, and
a region in which the lymph-node-specific contrast lies below the second set MR threshold value and in which the metabolic activity lies below the second set PET threshold value,
wherein the first set MR threshold value is greater than or equal to the second set MR threshold value,
the first set PET threshold value is greater than or equal to the second set PET threshold value, and
the first and second set MR threshold values are set separately from the first and second set PET threshold values; and
displaying the generated image.

2. The method as claimed in claim 1 , wherein the metabolic activity within the volume section is recorded on the basis of the PET data in that a corresponding tracer is administered to the examination subject prior to the acquisition of the PET data.

3. The method as claimed in claim 2 , wherein the tracer is fluorodeoxyglucose.

4. The method as claimed in claim 1 , wherein the lymph-node-specific contrast is recorded on the basis of the MR data in that a lymphotropic contrast agent is administered to the examination subject prior to the acquisition of the MR data.

5. The method as claimed in claim 4 , wherein the lymphotropic contrast agent is iron oxide or perfluorocarbon.

6. A non-transitory electronically readable data medium, on which is stored electronically readable control information which is embodied in such a way that when the data medium is used in a control device of a combined MR/PET apparatus, the control information performs the method as claimed in claim 1 .

7. The method as claimed in claim 1 , wherein the image is generated in that a mask is created for the PET data on the basis of the acquired MR data, opacity of the mask in a region of the image is set as a function of a signal intensity recorded on the basis of the MR data in a region of the volume section corresponding to said region, a PET image is generated from the PET data, and the image is generated in that the PET image is masked by way of the mask.

8. The method as claimed in claim 7 , wherein the opacity in a region of the image is high if the signal intensity of the MR data in a region of the volume section corresponding to said region is high, or the opacity in a region of the image is low if the signal intensity of the MR data in a region of the volume section corresponding to said region is high.

9. The method as claimed in claim 8 , wherein lymph nodes in the volume section are segmented on the basis of the MR data, and regions of the mask which correspond to none of the segmented lymph nodes are generated as opaque.

10. A non-transitory computer readable medium including program segments for, when executed on a computer device, causing the computer device to implement the method of claim 1 .

11. The method of claim 1 , wherein the following regions of the image are distinguishable from a remainder of the image,
the region in which the lymph-node-specific contrast lies above the first set MR threshold value and in which the metabolic activity lies above the first set PET threshold value,
the region in which the lymph-node-specific contrast lies above the first set MR threshold value and in which the metabolic activity lies below the second set PET threshold value,
the region in which the lymph-node-specific contrast lies below the second set MR threshold value and in which the metabolic activity lies above the first set PET threshold value, and
the region in which the lymph-node-specific contrast lies below the second set MR threshold value and in which the metabolic activity lies below the second set PET threshold value.

12. The method of claim 1 , wherein each of the plurality of predefined regions are visually distinguishable from each other and the remainder of the image.

13. A method as for visualizing lymph nodes in a volume section of an examination subject by way of a combined MR/PET apparatus, the method comprising:
acquiring PET data of the volume section, by way of a positron emission detector, to record, on the basis of the acquired PET data, a metabolic activity per PET voxel within the volume section;
acquiring MR data of the volume section, by way of a magnetic resonance system, to record, on the basis of the acquired MR data, a lymph-node-specific contrast per region of the volume section; and
generating an image as a function of metabolic activity recorded per PET voxel and as a function of the lymph-node-specific contrast recorded per region, abnormal lymph nodes being visualized in the image as being distinguishable from normal lymph nodes, wherein lymph nodes which are embedded in fat are segmented on the basis of the acquired MR data, a size of the segmented lymph nodes is determined, and an activity within a PET voxel recorded on the basis of the acquired PET data is assigned in full to a volume of a segmented lymph node recorded within the PET voxel if the size of the segmented lymph node is less than a size of the PET voxel, and the image generated to present at least one of the following regions of the image as being visually distinguishable from a remainder of the image:
a region in which the lymph-node-specific contrast lies above a first MR threshold value and in which the metabolic activity lies above a first PET threshold value,
a region in which the lymph-node-specific contrast lies above the first MR threshold value and in which the metabolic activity lies below a second PET threshold value,
a region in which the lymph-node-specific contrast lies below a second MR threshold value and in which the metabolic activity lies above the first PET threshold value, and
a region in which the lymph-node-specific contrast lies below the second MR threshold value and in which the metabolic activity lies below the second PET threshold value,
wherein the first MR threshold value is greater than or equal to the second MR threshold value, and
the first PET threshold value is greater than or equal to the second PET threshold value; and
displaying the genera

Assignees

• Schmidt Sebastian
• Siemens Ag

Inventors

• Schmidt Sebastian

Classifications

• A61B6/4417

  related to combined acquisition of different diagnostic modalities · CPC title

• A61B6/037 Primary

  Emission tomography · CPC title

• A61B5/415

  the glands, e.g. tonsils, adenoids or thymus · CPC title

• G06T2207/10088

  Magnetic resonance imaging [MRI] · CPC title

• G06T2207/30004

  Biomedical image processing · CPC title