Electrical detection using confined fluids

Patent metadata

Field	Value
Publication number	US-9110010-B2
Application number	US-11802808-A
Country	US
Kind code	B2
Filing date	May 9, 2008
Priority date	May 11, 2007
Publication date	Aug 18, 2015
Grant date	Aug 18, 2015

Abstract

A device having: a laminar flow channel for liquids; two or more electrodes; a confining fluid inlet; a sample inlet; and a meter for measuring the impedance of any fluid between the electrodes. The device may have one or more specific binding sites, or it may have sheathing and unsheathing fluid transporting structures. A method of: providing the device; flowing a confining fluid and a conductive liquid that may contain cells or particles through the channel as described herein; and measuring the impedance between the electrodes.

First claim

What is claimed is:

1. A device comprising:
a laminar flow channel for liquids having an interior surface;
one or more specific binding sites on the interior surface that can bind to a cell or particle of interest;
two or more electrodes on the interior surface;
wherein the binding sites are not on any of the electrodes;

a confining fluid inlet positioned to flow a confining fluid through the channel;
a sample inlet positioned to flow a conductive liquid between the con…

Assignees

• Ateya Daniel A
• Howell Jr Peter B
• Ligler Frances S
• Us Navy

Inventors

• Ateya Daniel A
• Howell Jr Peter B
• Ligler Frances S

Classifications

• G01N27/3276 Primary

  Physics · mapped topic